关键词:

肺癌, 参芪扶正液, 癌因性疲乏, 免疫功能, 化疗相关不良反应, 生存质量

Abstract:

Objective　To observe the effect of Shenqi Fuzheng Liquid on improving cancer-induced fatigue, immune function, and adverse chemotherapy reactions in patients with lung cancer. Methods　This was a prospective study. A total of 123 patients with lung cancer who received treatment in Nanyang First People's Hospital from January 2021 to May 2022 were included as the study objects. The patients were divided into a control group (61 cases) and an observation group (62 cases) by the lottery method. There were 40 males and 21 females in the control group; they were (60.44±5.18) years old. There were 42 males and 20 females in the observation group; they were (60.27±5.35) years old. Both groups took routine chemotherapy; in addition, the observation group took Shenqi Fuzheng Liquid. The immune function before and after the treatment was compared between the two groups. The improvement of cancer-induced fatigue 7, 14, and 30 days after the treatment was observed. The occurrence of chemotherapy related adverse reactions and quality of life of the two groups were analyzed and compared through 6-month short-term follow-up. χ² and t tests were applied. Results　Before the treatment, there were no statistical differences in the immune function and score of Piper Fatigue Scale (PFS) between the two groups (all P>0.05). After the treatment, the CD3+ and CD4+ T lymphocyte subsets were higher and the CD8+ was lower in the observation group than in the control group [(70.35±10.46)% vs. (65.44±10.27) %, (40.22±8.47)% vs. (35.25±8.33)%, and (35.44±5.36)% vs. (38.25±5.46)%; all P<0.05]. The PFS scores 1,5, and 10 d after the treatment in the observation group were lower than those in the control group [(28.44±4.69) vs. (31.22±4.33), (23.39±5.37) vs. (26.44±5.82), and (20.27±2.28) vs. (23.47±4.15); all P<0.05]. During the follow-up period, the incidence of adverse chemotherapy reactions in the observation group was lower than that in the control group [9.68% (6/62) vs. 21.31% (13/61)]. The scores of Karnofsky Performance Status (KPS), quality of life (QOL), and Zubrod Performance Status (ZPS) in the observation group were better than those in the control group [(75.22±5.31) vs. (72.19±5.28), (48.44±5.23) vs. (45.15±5.19), and (2.12±0.75) vs. (3.32±1.26); all P<0.05]. Conclusion　Shenqi Fuzheng Liquid can effectively improve the immune function and cancer-induced fatigue level in patients with lung cancer chemotherapy, and has positive significance in reducing the risk of chemotherapy-related adverse reactions and improving the quality of life.

Key words:

Lung cancer, Shenqi Fuzheng Liquid, Cancer-related fatigue, Immune function, Chemotherapy-related adverse reactions, Quality of life