关键词:

乳腺癌, MRI, 超声, 血流动力学

Abstract:

Objective　To investigate the diagnostic value of blood flow parameters of enhanced MRI scan combined with ultrasound for breast cancer. Methods　Eighty patients with suspected breast cancer treated at Huangshi Central Hospital from January 2020 to January 2023 were selected as the study objects and divided into a control group (13 cases) and a confirmed group (67 cases) according to the clinical and pathological examination results. The control group were (53.12±8.79) years old, and the confirmed group (54.35±7.96). The diagnostic results by the two methods were compared. The enhanced MRI scan parameters [volume transfer constant (Ktrans), rate constant (Kep), and vascular extracellular space volume ratio (Ve)] and ultrasound parameters [(blood beat index (PI), flow resistance index (RI), and peak flow rate (PSV)] were compared between the two groups. Comparisons of the measurement and count data were performed using the t test and χ² test, respectively. The diagnostic values of enhanced MRI scan parameters and ultrasound parameters alone and their combination for breast cancer were evaluated using the receiver operating characteristic curve (ROC). Results　In the 67 patients confirmed with breast cancer, there was no statistical difference in the accurate diagnostic rate between the MRI and ultrasound [91.04% (61/67) vs. 92.54% (62/67); P>0.05], but the MRI had a higher misdiagnosis rate than ultrasound [6.15% (4/67) vs. 0; P<0.05]. The results of the ROC showed that individual Ktrans [area under the curve (AUC)=0.711], Kep (AUC=0.739), PI (AUC=0.756), RI (AUC=0.846), and PSV (AUC=0.755) had some value in breast cancer diagnosis. The AUC of the combination of the 2 enhanced MRI scan parameters was 0.790; the AUC of the combination of the 3 ultrasound parameters was 0.928; the AUC of the combination of the 5 parameters was 0.954. Conclusion　The enhanced MRI scan parameters and ultrasound parameters of blood flow in patients with breast cancer are high. The combination of MRI and ultrasound is of some clinical value.

Key words:

Breast cancer, MRI, Ultrasound, Hemodynamics