关键词:

胆石症, 腹腔镜胆囊切除术, 四磨汤, 胃肠激素, 胃肠功能

Abstract:

Objective　To investigate the effect of Simo decoction on gastrointestinal hormone level in patients with cholelithiasis after operation. Methods　A total of 102 patients with cholelithiasis admitted to Lianyungang Traditional Chinese Medicine Hospital from January 2019 to January 2022 were selected for this study, who all underwent laparoscopic cholecystectomy (LC). After operation, the patients were divided into an observation group and a control group according to the random number table method, with 51 cases in each group. In the observation group, there were 20 males and 31 females; the patients were aged 22-64 years, with an age of (43.17±3.74) years old; they were treated with conventional anti-infection and liver protection therapy plus Simo decoction. In the control group, there were 21 males and 30 females; the patients were aged 21-63 years, with an age of (42.62±3.49) years old; they were given routine anti-infection and liver protection treatment. The treatment effects of the two groups were compared, and the traditional Chinese medicine (TCM) symptom scores of abdominal distension, loss of appetite, pulse string, chest tightness and nausea, frequent belching, and red tongue and white fur were compared between the two groups before and after treatment. The anal exhaust time, bowel call relief time, defecation time, and feeding time of the two groups were compared. The levels of gastrin (GAS), motilin (MTL), and somatostatin (SS) before and after treatment were compared between the two groups, and the adverse reactions were compared between the two groups. Independent sample t test and paired t test were used for the measurement data, and χ² test was used for the count data. Results　The total effective rate of the observation group was significantly higher than that of the control group [92.16% (47/51) vs. 70.59% (36/51)], with a statistically significant difference (χ²=7.826, P=0.005). After treatment, the TCM symptom scores of abdominal distension, loss of appetite, pulse string, chest tightness and nausea, frequent belching, and red tongue and white fur in the observation group were lower than those in the control group (all P<0.05). Compared with those in the control group, the duration of anal exhaust [(33.56±5.44) h], bowel sound relief time [(18.76±3.28) h], defecation time [(40.56±6.67) h], and feeding time [(37.27±6.24) h] were shorter in the observation group (all P<0.05). After treatment, the level of GAS [(112.87±18.25) ng/L] and MTL [(203.81±22.13) ng/L] in the observation group were lower than those in the control group, and the level of SS [(48.96±8.09) ng/L] was higher than that in the control group (all P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group [3.92% (2/51) vs. 17.64% (9/51)], with a statistically significant difference (χ²=4.993, P=0.025). Conclusion　Simo decoction can effectively relieve the clinical symptoms in cholelithiasis patients after operation, shorten the recovery time of various indexes of gastrointestinal function, regulate the gastrointestinal hormone level, and have high safety and less adverse reactions.

Key words:

Cholelithiasis, Laparoscopic cholecystectomy, Simo decoction, Gastrointestinal hormones, Gastrointestinal function