关键词:

结直肠癌, 腹腔镜手术, 高糖溶液, 胃肠功能, 炎症水平, 胰岛素抵抗指数, 并发症

Abstract:

Objective　To investigate the effects of oral high-glucose solution before laparoscopy on postoperative gastrointestinal function, inflammation response, and insulin resistance in patients with colorectal cancer. Methods　A total of 78 patients with colorectal cancer admitted to Lianyungang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from May 2020 to July 2022 were selected as the study objects. They were divided into 2 groups by the random number table method: an observation group (39 cases) and a control group (39 cases). In the observation group, there were 20 males and 19 females, aged 38-75 (56.65±8.43) years, Dukes stage: 21 cases of stage Ⅰ and 18 cases of stage Ⅱ. In the control group, there were 19 males and 20 females, aged 39-74 (55.79±8.39) years, Dukes stage: 22 cases of stage Ⅰ and 17 cases of stage Ⅱ. The control group received conventional treatment, and the observation group received oral high-glucose solution. Postoperative gastrointestinal function, inflammatory response, insulin resistance index, and complications were compared between the two groups. Independent sample t test, paired t test, and χ² test were used. Results　After treatment, the postoperative anal exhaust time, the first postoperative defecation time, and the hospital stay in the observation group were (23.97±2.85) h, (14.35±5.43) h, and (5.69±0.87) d, respectively, which were shorter than those in the control group [(34.68±3.94) h, (21.06±7.47) h, and (9.52±1.14) d], with statistically significant differences (all P<0.05). After treatment, the levels of tumor necrosis factor α (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6) in the observation group were (141.85±30.29) ng/L, (8.69±2.05) mg/L, and (7.34±0.93) ng/L, respectively, which were lower than those in the control group [(182.46±33.37) ng/L, (15.33±2.78) mg/L, and (9.97±1.54) ng/L], with statistically significant differences (all P<0.05). After treatment, the insulin resistance index of the observation group was lower than that of the control group [(5.14±0.31) vs. (7.75±0.96)], with a statistically significant difference (P<0.05). After treatment, the total incidence of complications in the observation group was 10.25% (4/39), which was lower than that in the control group [28.21% (11/39)], with a statistically significant difference (P<0.05). Conclusion　The oral administration of high-glucose solution before laparoscopy can effectively improve the postoperative gastrointestinal function in patients with colorectal cancer, reduce the level of inflammation, improve their insulin resistance, and reduce the incidence of complications, which is worthy of promotion.

Key words:

Colorectal cancer, Laparoscopy, High-glucose solution, Gastrointestinal function, Inflammation level, Insulin resistance index,  , Complications