国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (22): 3162-3165.DOI: 10.3760/cma.j.issn.1007-1245.2023.22.003
肠道菌群与肠道疾病的研究进展
付新年1 郑盛2 杨涓2
1大理大学,大理 671003;2大理大学第二附属医院 云南省第三人民医院消化内科,昆明 650011
收稿日期:
2023-06-25
出版日期:
2023-11-15
发布日期:
2023-11-23
通讯作者:
杨涓,Email:53573885@qq.com
基金资助:
云南省科技厅科技计划项目(2018FH001-076、2018FH001-080);云南省教育厅科学研究基金立项项目(2023J0926);大理大学第八期教育教学改革研究项目(2022JGYX08-01、2022JGYX08-02)
Research progress of intestinal flora and intestinal diseases
Fu Xinnian1, Zheng Sheng2, Yang Juan2
1 Dali University, Dali 671003, China; 2 Department of Gastroenterology, Yunnan Third People's Hospital, Second Hospital, Dali University, Kunming 650011, China
Received:
2023-06-25
Online:
2023-11-15
Published:
2023-11-23
Contact:
Yang Juan, Email: 53573885@qq.com
Supported by:
Project of Scientific and Technological Plan of Yunnan Department of Science and Technology (2018FH001-076 and 2018FH001-080); Project Supported by Scientific Research Fund of Yunnan Education Department (2023J0926); Research Project of Eighth Education and Teaching Reform of Dali University (2022JGYX08-01 and 2022JGYX08-02)
摘要:
肠道菌群与肠道疾病的发生发展有着紧密的联系,它在维持肠道稳态方面起着重要作用。本文对肠道菌群与肠道疾病[结直肠息肉、结直肠癌(CRC)、炎症性肠病(IBD)、肠易激综合征(IBS)]的研究进展展开综述,旨在为肠道疾病的预防、诊断及治疗提供参考。
付新年 郑盛 杨涓.
肠道菌群与肠道疾病的研究进展 [J]. 国际医药卫生导报, 2023, 29(22): 3162-3165.
Fu Xinnian, Zheng Sheng, Yang Juan.
Research progress of intestinal flora and intestinal diseases [J]. International Medicine and Health Guidance News, 2023, 29(22): 3162-3165.
[1] Guo X, Okpara ES, Hu W,et al. Interactive relationships between intestinal flora and bile acids[J]. Int J Mol Sci,2022,23(15):8343.DOI: 10.3390/ijms23158343. [2] Fu Q, Song T, Ma X,et al. Research progress on the relationship between intestinal microecology and intestinal bowel disease[J]. Animal Model Exp Med,2022,5(4):297-310.DOI: 10.1002/ame2.12262. [3] Chen Y, Zhou J, Wang L. Role and mechanism of gut microbiota in Human Disease[J]. Front Cell Infect Microbiol,2021,11:625913.DOI: 10.3389/fcimb.2021.625913. [4] Ma PJ, Wang MM, Wang Y. Gut microbiota: a new insight into lung diseases[J]. Biomed Pharmacother,2022,155:113810.DOI: 10.1016/j.biopha.2022.113810. [5] Meng X, Zhang G, Cao H,et al. Gut dysbacteriosis and intestinal disease: mechanism and treatment[J]. J Appl Microbiol,2020,129(4):787-805.DOI: 10.1111/jam.14661. [6] Sullivan BA, Noujaim M, Roper J. Cause, epidemiology, and histology of polyps and pathways to colorectal cancer[J]. Gastrointest Endosc Clin N Am,2022,32(2):177-194.DOI: 10.1016/j.giec.2021.12.001. [7] Zhong X, Wang Y, Xu J,et al. Gut microbiota signatures in tissues of the colorectal polyp and normal colorectal mucosa, and faeces[J]. Front Cell Infect Microbiol,2023,12:1054808.DOI: 10.3389/fcimb.2022.1054808. [8] 徐俊,陈冰心,朱永亮,等. 结直肠腺瘤的肠道微生态分析及临床意义[J]. 中国医药导报,2022,19(16):30-33. [9] Liang S, Mao Y, Liao M,et al. Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps[J]. Int J Biol Sci,2020,16(1):135-146.DOI: 10.7150/ijbs.37399. [10] Hale VL, Chen J, Johnson S,et al. Shifts in the fecal microbiota associated with adenomatous polyps[J]. Cancer Epidemiol Biomarkers Prev,2017,26(1):85-94.DOI: 10.1158/1055-9965.EPI-16-0337. [11] Liang JQ, Li T, Nakatsu G,et al. A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer[J]. Gut,2020,69(7):1248-1257.DOI: 10.1136/gutjnl-2019-318532. [12] Pop OL, Vodnar DC, Diaconeasa Z,et al. An overview of gut microbiota and colon diseases with a focus on adenomatous colon polyps[J]. Int J Mol Sci,2020,21(19):7359.DOI: 10.3390/ijms21197359. [13] Cheng Y, Ling Z, Li L. The intestinal microbiota and colorectal cancer[J]. Front Immunol,2020,11:615056.DOI: 10.3389/fimmu.2020.615056. [14] Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A,et al. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli[J]. Nature,2020,580(7802):269-273.DOI: 10.1038/s41586-020-2080-8. [15] Yu LC, Wei SC, Li YH,et al. Invasive pathobionts contribute to colon cancer initiation by counterbalancing epithelial antimicrobial responses[J]. Cell Mol Gastroenterol Hepatol,2022,13(1):57-79.DOI: 10.1016/j.jcmgh.2021.08.007. [16] Wu Y, Jiao N, Zhu R,et al. Identification of microbial markers across populations in early detection of colorectal cancer[J]. Nat Commun,2021 ,12(1):3063.DOI: 10.1038/s41467-021-23265-y. [17] Reis SAD, da Conceição LL, Peluzio MDCG. Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease[J]. J Med Microbiol,2019,68(10):1391-1407.DOI: 10.1099/jmm.0.001049. [18] Yinhang W, Wei W, Jing Z,et al. Biological roles of toll-like receptors and gut microbiota in colorectal cancer[J]. Future Microbiol,2022,17:1071-1089.DOI: 10.2217/fmb-2021-0072. [19] Rezasoltani S, Ghanbari R, Looha MA,et al. Expression of main toll-like receptors in patients with different types of colorectal polyps and their relationship with gut microbiota[J]. Int J Mol Sci,2020,21(23):8968.DOI: 10.3390/ijms21238968. [20] Gao C, Qiao T, Zhang B,et al. TLR9 signaling activation at different stages in colorectal cancer and NF-kappaB expression[J]. Onco Targets Ther,2018,11:5963-5971.DOI: 10.2147/OTT.S174274. [21] Sheng Q, Du H, Cheng X,et al. Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites[J]. Oncol Lett,2019,18(5):4834-4844.DOI: 10.3892/ol.2019.10841. [22] Feng J, Gong Z, Sun Z,et al. Microbiome and metabolic features of tissues and feces reveal diagnostic biomarkers for colorectal cancer[J]. Front Microbiol,2023,14:1034325.DOI: 10.3389/fmicb.2023.1034325. [23] Chen F, Dai X, Zhou CC,et al. Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma[J]. Gut,2022,71(7):1315-1325. DOI: 10.1136/gutjnl-2020-323476. [24] Miyoshi J, Chang EB. The gut microbiota and inflammatory bowel diseases[J]. Transl Res,2017,179:38-48.DOI: 10.1016/j.trsl.2016.06.002. [25] Hu Y, Chen Z, Xu C,et al. Disturbances of the gut microbiota and microbiota-derived metabolites in inflammatory bowel Disease[J]. Nutrients,2022,14(23):5140.DOI: 10.3390/nu14235140. [26] Inczefi O, Bacsur P, Resál T,et al. The influence of nutrition on intestinal permeability and the microbiome in health and disease[J]. Front Nutr,2022,9:718710.DOI: 10.3389/fnut.2022.718710. [27] Caruso R, Lo BC, Núñez G. Host-microbiota interactions in inflammatory bowel disease[J]. Nat Rev Immunol,2020,20(7):411-426.DOI: 10.1038/s41577-019-0268-7. [28] Colman RJ, Tsai YT, Jackson K,et al. Achieving target infliximab drug concentrations improves blood and fecal neutrophil biomarkers in crohn's disease[J]. Inflamm Bowel Dis,2021,27(7):1045-1051.DOI: 10.1093/ibd/izaa241. [29] Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review[J]. Antonie Van Leeuwenhoek,2020,113(12):2019-2040.DOI: 10.1007/s10482-020- 01474-7. [30] Lavelle A, Sokol H. Gut microbiota-derived metabolites as key actors in inflammatory bowel disease[J]. Nat Rev Gastroenterol Hepatol,2020,17(4):223-237.DOI: 10.1038/s41575-019-0258-z. [31] Sasaki K, Inoue J, Sasaki D,et al. Construction of a model culture system of human colonic microbiota to detect decreased lachnospiraceae abundance and butyrogenesis in the feces of ulcerative colitis patients[J]. Biotechnol J,2019,14(5):e1800555.DOI: 10.1002/biot.201800555. [32] Chen M, Feng Y, Liu W. Efficacy and safety of probiotics in the induction and maintenance of inflammatory bowel disease remission: a systematic review and meta-analysis[J]. Ann Palliat Med,2021,10(11):11821-11829.DOI: 10.21037/apm-21-2996. [33] Leonardi I, Paramsothy S, Doron I,et al. Fungal trans-kingdom dynamics linked to responsiveness to fecal microbiota transplantation (FMT) therapy in ulcerative colitis[J]. Cell Host Microbe,2020,27(5):823-829.e3.DOI: 10.1016/j.chom.2020.03.006. [34] Kim GH, Lee K, Shim JO. Gut bacterial dysbiosis in irritable bowel syndrome: a case-control study and a cross-cohort analysis using publicly available data sets[J]. Microbiol Spectr,2023,11(1):e0212522.DOI: 10.1128/spectrum.02125-22. [35] Mamieva Z, Poluektova E, Svistushkin V,et al. Antibiotics, gut microbiota, and irritable bowel syndrome: what are the relations?[J]. World J Gastroenterol,2022,28(12):1204-1219.DOI: 10.3748/wjg.v28.i12.1204. [36] Ji M, Huang H, Lan X. Correlation between intestinal microflora in irritable bowel syndrome and severity[J]. Dis Markers,2022,2022:1031844.DOI: 10.1155/2022/1031844. [37] Frost F, Kacprowski T, Rühlemann MC,et al. Functional abdominal pain and discomfort (IBS) is not associated with faecal microbiota composition in the general population[J]. Gut,2019,68(6):1131-1133.DOI: 10.1136/gutjnl-2018-316502. [38] Maharshak N, Ringel Y, Katibian D,et al. Fecal and mucosa-associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome[J]. Dig Dis Sci,2018,63(7):1890-1899.DOI: 10.1007/s10620-018-5086-4. [39] Asha MZ, Khalil SFH. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome: a systematic review and meta-analysis[J]. Sultan Qaboos Univ Med J,2020,20(1):e13-e24.DOI: 10.18295/squmj.2020.20.01.003. [40] El-Salhy M, Hatlebakk JG, Gilja OH,et al. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study[J]. Gut,2020,69(5):859-867.DOI: 10.1136/gutjnl-2019-319630. [41] Sun JR, Kong CF, Qu XK,et al. Efficacy and safety of probiotics in irritable bowel syndrome: a systematic review and meta-analysis[J]. Saudi J Gastroenterol,2020,26(2):66-77.DOI: 10.4103/sjg.SJG_384_19. |
[1] | 刘玉姣 王超 刘菲. 中西医结合治疗产后盆底肌筋膜疼痛的研究进展 [J]. 国际医药卫生导报, 2023, 29(9): 1204-1207. |
[2] | 王泽川 黄月琴. 急性髓系白血病靶向药物治疗新进展 [J]. 国际医药卫生导报, 2023, 29(8): 1045-1048. |
[3] | 徐仕杰 罗泽斌 陈晓东. CT肺动脉成像在肺栓塞诊治中的应用进展 [J]. 国际医药卫生导报, 2023, 29(8): 1053-1056. |
[4] | 张衡 潘广涛 殷鸣 张平 尹霞. 自体脂肪移植在整形外科中的研究进展 [J]. 国际医药卫生导报, 2023, 29(7): 889-892. |
[5] | 耿松 卢清军 任翔 蒋宏. MicroRNAs在结直肠炎癌转化过程中的作用 [J]. 国际医药卫生导报, 2023, 29(7): 903-909. |
[6] | 王凤燕 王胜果 于呈祥 韩志浩. 标准化碘密度诊断结直肠癌淋巴结转移的价值 [J]. 国际医药卫生导报, 2023, 29(7): 923-928. |
[7] | 吴雪梅 张玉杰 解胜华. 银屑病与心血管共病关系的研究进展 [J]. 国际医药卫生导报, 2023, 29(4): 453-456. |
[8] | 耿泽月 张兴凯 杜刚强 周楠 赵冬阳 王志刚. 髓内钉治疗股骨中下段骨折的并发症分析 [J]. 国际医药卫生导报, 2023, 29(23): 3321-3324. |
[9] | 张辰喜 王鹏飞 潘欣 刘紫仪 张勇. 艾司氯胺酮在临床麻醉中的应用进展 [J]. 国际医药卫生导报, 2023, 29(23): 3325-3329. |
[10] | 肖曦 石斗飞. 维生素C在呼吸道感染中应用的研究进展 [J]. 国际医药卫生导报, 2023, 29(23): 3330-3335. |
[11] | 司航 王娜娜 刘素素 张骞. PP1A在肿瘤发生发展过程中的作用及研究进展 [J]. 国际医药卫生导报, 2023, 29(23): 3336-3340. |
[12] | 付志鹏 郑盛 杨涓. 肝硬化患者营养评价方法研究进展 [J]. 国际医药卫生导报, 2023, 29(23): 3341-3344. |
[13] | 刘丽英 魏丽娟 张妙贤 唐盈玉 张超米. 炎症性肠病患儿父母疾病认知调查分析 [J]. 国际医药卫生导报, 2023, 29(23): 3497-3500. |
[14] | 蔡金凤 王洪财 葛汝丽. 肠道菌群失衡在帕金森病α-突触核蛋白诱导小胶质细胞活化中的作用 [J]. 国际医药卫生导报, 2023, 29(22): 3153-3157. |
[15] | 谢爱霞 李强强 何炎鸿 化得武 陈丽萍 薛建军. B超引导下注射富血小板血浆联合神经阻滞治疗肩周炎的研究进展 [J]. 国际医药卫生导报, 2023, 29(22): 3157-3161. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||