关键词: 环状RNA, 竞争性内源RNA, 心血管疾病, 心力衰竭, 综述

Abstract:

Heart failure is an increasingly serious public health issue and represents the end stage of many cardiovascular diseases. Despite the widespread adoption of evidence-based medications and mechanical circulatory support, an unacceptable number of patients continue to suffer from functional impairment, poor quality of life, and early mortality due to heart failure. Circular RNA (circRNA) is a novel class of endogenous non-coding RNA that has been shown in recent studies to be closely associated with the diagnosis of heart failure, the formation of coronary atherosclerotic plaques, and the development of myocardial infarction and heart failure. This paper reviews the role and mechanisms of circRNA structure in heart failure, providing new insights for the diagnosis and treatment of heart failure.

Key words: Circular RNA, Competing endogenous RNA, Cardiovascular diseases, Heart failure, Review