关键词:

肺炎, 清热解毒汤, 加减治疗, 可溶性白细胞介素-2受体, 核转录因子

Abstract:

Objective　To investigate the effect of modified Qingre Jiedu decoction in the treatment of elderly patients with pneumonia and the influence on serum soluble interleukin-2 receptor (sIL-2R) and nuclear factor-κB (NF-κB) levels. Methods　From September 2020 to September 2023, 116 elderly patients with pneumonia admitted to Xi'an International Medical Center Hospital were selected for the study. According to the random number table method, they were allocated to the control group (58 cases) and the treatment group (58 cases). In the control group, there were 31 males and 27 females, with an age of (62.35±6.58) years old and a disease duration of (5.75±1.14) days. In the treatment group, there were 33 males and 25 females, with an age of (61.98±6.63) years old and a disease duration of (5.81±1.07) days. The control group was given conventional treatment and the treatment group was treated with modified Qingre Jiedu decoction on the basis (400 ml of the decoction was taken daily, in two divided doses, taken warm in the morning and evening). All the patients were treated for 14 days. The clinical efficacy, traditional Chinese medicine (TCM) syndrome scores, levels of inflammatory factors, sIL-2R, and NF-κB were compared between the two groups. The occurrence of adverse reactions was recorded. Statistical analysis was conducted using χ² test and t test. Results　The clinical response rate of the treatment group was higher than that of the control group [91.38% (53/58) vs. 70.69% (41/58)], with a statistically significant difference (P<0.05). Before treatment, there was no statistically significant difference in the score of cough, expectoration, fever, or chest tightness between the two groups (all P>0.05); after treatment, the scores of the above-mentioned TCM syndromes in both groups decreased, and which were lower in the treatment group than in the control group (all P<0.05). Before treatment, there was no statistically significant difference in the levels of inflammatory factors [C-reactive protein (CRP), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α)], sIL-2R, or NF-κB between the two groups (all P>0.05); after treatment, the levels of these indicators in both groups decreased, and which were lower in the treatment group than in the control group (all P<0.05). No obvious adverse reactions were observed in the two groups. Conclusion　Modified Qingre Jiedu decoction is effective in the treatment of elderly patients with pneumonia, which can significantly improve the clinical symptoms, and lower the levels of inflammatory factors, sIL-2R, and NF-κB, with high safety.

Key words:

Pneumonia, Qingre Jiedu , decoction, Modified treatment, Soluble interleukin-2 receptor, Nuclear factor-κB