关键词:

耐药肺结核, 流行病学, 治疗转归

Abstract:

Objective　Analyze the epidemiological characteristics and treatment outcomes of drug-resistant pulmonary tuberculosis patients in Baoji city during six years. Methods　The general data of 211 patients with drug-resistant pulmonary tuberculosis in Baoji city from January 1, 2016 to December 31, 2021 were collected, including age, gender, occupation, previous history of anti-tuberculosis treatment, patient diagnosis type, registration classification, treatment classification, whether receiving anti-tuberculosis treatment, reasons for stopping treatment, drug sensitivity results, and treatment outcome. Chi-square trend test and χ² test were used for statistical analysis. Results　From 2016 to 2021, a total of 211 cases of drug-resistant pulmonary tuberculosis were reported in Baoji city. The average annual incidence rate was 1.02 per 100,000 people, and the incidence rate showed an overall upward trend (P<0.05). There were 144 male cases (68.25%) and 67 female cases (31.75%), with a male-to-female ratio of 2.15:1; the age range was 15 to 85 years old, with 153 cases (72.51%) aged 25 to 64 years old; 149 cases (70.62%) were farmers. The highest average incidence rate was in the mountainous county of Long county (1.83 per 100,000), followed by the urban district of Jintai district (1.35 per 100,000) and the mountainous county of Linyou county (1.17 per 100,000). Comparisons of the average incidence rates among different counties showed statistically significant differences (P<0.05). The top three drugs with drug resistance were rifampicin [93.36% (197/211)], isoniazid [74.88% (158/211)], and ethambutol [31.28% (66/211)], and the resistance rate of fluoroquinolone drugs was relatively low (P<0.05). 158 cases (74.88%) were successfully treated (including cure and completion of treatment course), and 53 cases (25.12%) were not successfully treated. The top three reasons for unsuccessful treatment were drug intolerance [41.51% (22/53)], poor treatment compliance [22.64% (12/53)], and refusal of treatment (including excessive economic burden) [13.21% (7/53)]. Conclusion　From 2016 to 2021, the incidence of drug-resistant pulmonary tuberculosis in Baoji city was relatively high. The patients were mainly male, middle-aged and young adults, and farmers. The drug resistance was mainly composed of rifampicin, isoniazid and ethambutol. The treatment success rate was relatively high. The reasons for unsuccessful treatment were mainly drug intolerance, poor treatment compliance and refusal to treat (including excessive economic burden).

Key words:

Drug-resistant pulmonary tuberculosis, Epidemiology, Treatment outcome