关键词: 2型糖尿病,  ,  , 血清游离脂肪酸,  ,  , 脂联素,  ,  , 视网膜病变

Abstract:

Objective　To investigate the relationship of serum levels of adiponectin (ADPN) and nonestesterified fatty acid (NEFA) with diabetic retinopathy (DR). Methods　Thirty-four patients with type 2 diabetes mellitus (T2DM) treated at Binzhou Medical University Hospital from November 2021 to May 2022 were selected as the study objects, including 18 males and 16 females who were 36-75 years old. According to whether they had DR, the patients were divided into a non-DR group (18 cases) and a DR group (16 cases). Sixteen healthy examinees taking physical examination at Binzhou Medical University Hospital during the same period were selected as a health control group, including 9 males and 7 females who were 33-74 years old. The levels of NEFA, ADPN, blood glucose, cholesterol (CHO), low-density lipoprotein (LDL), triglyceride (TG), and high-density lipoprotein (HDL) in all the subjects were detected. t test was used for the statistical analysis. Results　The levels of NEFA and ADPN in the DR group were (1.03±0.38) mmol/L and (5.64±1.57) mg/L, the levels in the non-DR group (0.47±0.13) mmol/L and (7.99±1.98) mg/L, and the levels in the healthy control group （0.47±0.13） mmol/L and （7.99±1.98） mg/L， with statistical differences (both P<0.05). Conclusion　Serum levels of SNEFA and ADPN are associated with DR in patients with T2DM.

Key words: Type 2 diabetes mellitus,  , Nonestesterified fatty acid,  , Adiponectin,  , Retinopathy