Abstract:

Heart failure is an increasingly serious public health issue and represents the end stage of many cardiovascular diseases. Despite the widespread adoption of evidence-based medications and mechanical circulatory support, an unacceptable number of patients continue to suffer from functional impairment, poor quality of life, and early mortality due to heart failure. Circular RNA (circRNA) is a novel class of endogenous non-coding RNA that has been shown in recent studies to be closely associated with the diagnosis of heart failure, the formation of coronary atherosclerotic plaques, and the development of myocardial infarction and heart failure. This paper reviews the role and mechanisms of circRNA structure in heart failure, providing new insights for the diagnosis and treatment of heart failure.

Key words: Circular RNA, Competing endogenous RNA, Cardiovascular diseases, Heart failure, Review

摘要：

心力衰竭是一个日益严重的重大公共卫生问题，是众多心血管疾病的终末阶段。尽管广泛采用循证药物和机械循环辅助支持治疗，但仍有不可接受数量的患者因心力衰竭而遭受功能受损、生活质量差和早期死亡的问题。环状RNA（circRNA）是一类新型的内源性非编码RNA，在近些年的研究中，circRNA已经被证明与心力衰竭的诊断、冠状动脉粥样硬化斑块的形成、心肌梗死和心力衰竭的发生发展有着密切联系。本文从circRNA的结构在心力衰竭中的作用和机制进行综述，为心力衰竭的诊治提供新思路。

关键词: 环状RNA, 竞争性内源RNA, 心血管疾病, 心力衰竭, 综述