Abstract:

Objective　To investigate the relationship of serum levels of adiponectin (ADPN) and nonestesterified fatty acid (NEFA) with diabetic retinopathy (DR). Methods　Thirty-four patients with type 2 diabetes mellitus (T2DM) treated at Binzhou Medical University Hospital from November 2021 to May 2022 were selected as the study objects, including 18 males and 16 females who were 36-75 years old. According to whether they had DR, the patients were divided into a non-DR group (18 cases) and a DR group (16 cases). Sixteen healthy examinees taking physical examination at Binzhou Medical University Hospital during the same period were selected as a health control group, including 9 males and 7 females who were 33-74 years old. The levels of NEFA, ADPN, blood glucose, cholesterol (CHO), low-density lipoprotein (LDL), triglyceride (TG), and high-density lipoprotein (HDL) in all the subjects were detected. t test was used for the statistical analysis. Results　The levels of NEFA and ADPN in the DR group were (1.03±0.38) mmol/L and (5.64±1.57) mg/L, the levels in the non-DR group (0.47±0.13) mmol/L and (7.99±1.98) mg/L, and the levels in the healthy control group （0.47±0.13） mmol/L and （7.99±1.98） mg/L， with statistical differences (both P<0.05). Conclusion　Serum levels of SNEFA and ADPN are associated with DR in patients with T2DM.

Key words: Type 2 diabetes mellitus,  , Nonestesterified fatty acid,  , Adiponectin,  , Retinopathy

摘要：

目的　探讨血清脂联素（adiponectin，ADPN）、游离脂肪酸（nonestesterified fatty acid，NEFA）与糖尿病视网膜病变（diabetic retinopathy，DR）的关系。方法　选取2021年11月至2022年5月滨州医学院附属医院收治的34例2型糖尿病（type 2 diabetes mellitus，T2DM）患者为研究对象，男18例，女16例，年龄36～75岁。根据有无DR将患者分为非DR组18例和DR组16例。选取同期于滨州医学院附属医院体检的16例健康体检者为健康对照组，男9例，女7例，年龄33～74岁。检测所有受试者NEFA、ADPN、血糖、胆固醇（cholesterol，CHO）、低密度脂蛋白（low-density lipoprotein，LDL）、三酰甘油（triglyceride，TG）、高密度脂蛋白（high-density lipoprotein，HDL）等。采用t检验进行统计分析。结果　DR组NEFA、ADPN水平（1.03±0.38）mmol/L、（5.64±1.57）mg/L，非DR组（0.72±0.11）mmol/L、（6.08±1.79）mg/L，健康对照组（0.47±0.13）mmol/L、（7.99±1.98）mg/L，差异均有统计学意义（均P<0.05）。结论　血清NEFA、ADPN水平与T2DM患者DR相关。

关键词: 2型糖尿病,  ,  , 血清游离脂肪酸,  ,  , 脂联素,  ,  , 视网膜病变