Research progress of Notch signal pathway in cardiovascular diseases

doi:10.3760/cma.j.issn.1007-1245.2024.14.002

Abstract

Abstract:

With the increasingly prominent unhealthy lifestyle of Chinese residents, the impact of cardiovascular disease risk factors on their health is becoming more and more significant. The Annual Report on Cardiovascular Health and Diseases in China (2022) points out that the incidence of cardiovascular diseases in China is still increasing, and cardiovascular diseases are the primary cause of death for urban and rural residents in our country. The Notch signaling pathway plays an important role in the recovery of cardiac function in various cardiovascular diseases. Therefore, people are increasingly concerned about the role of Notch signaling pathway in the development of cardiovascular diseases. At the same time, the research in this area has also made certain progress. This article aims to explore the potential therapeutic targets of Notch signaling pathway and provide new pathways for the treatment of cardiovascular diseases by elucidating its mechanism of action.

Key words:

Notch signaling pathway, Cardiovascular diseases, Myocardial fibrosis, Myocardial infarction, Heart failure, Congenital heart disease, Progress

摘要：

随着我国居民不健康生活方式的日益突出，心血管疾病的危险因素对居民健康的影响越加显著。《中国心血管健康与疾病报告2022》指出，我国心血管疾病发病率仍持续增高，心血管疾病是我国城乡居民的首要死亡原因。Notch信号通路在多种心血管疾病的心脏功能恢复中起重要作用。因此，人们越来越关注Notch信号通路在心血管疾病发生、发展中的作用，同时研究也取得了一定的进展。本文旨在阐述Notch信号通路的在心血管疾病中的作用机制，探索其潜在的治疗靶点，为疾病的治疗提供新的途径。

关键词:

Notch信号通路, 心血管疾病, 心肌纤维化, 心肌梗死, 心力衰竭, 先天性心脏病, 进展

Liu Zhengxing, Zhao Ke, Shi Dayu, Zhao Jiahao, Shang Xue, Xu Huipu.

Research progress of Notch signal pathway in cardiovascular diseases [J]. International Medicine and Health Guidance News, 2024, 30(14): 2293-2296.

刘振兴赵珂时大宇赵嘉昊商雪徐会圃.

Notch信号通路在心血管疾病中的研究进展 [J]. 国际医药卫生导报, 2024, 30(14): 2293-2296.

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