International Medicine and Health Guidance News ›› 2024, Vol. 30 ›› Issue (8): 1291-1296.DOI: 10.3760/cma.j.issn.1007-1245.2024.08.013
• Topic: Cardiovascular Disease • Previous Articles Next Articles
Research progress of Wnt signaling pathway in acute myocardial infarction
Yang Shoujuan1, Zhang Haitao2, Cui Mingli1, Wang Jian1, Li Yang1, Cheng Yanli1
1 Department of Cardiology, Binzhou Medical University Hospital, Binzhou 256603, China; 2 Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou 256603, China
Received:
2023-10-19
Online:
2024-04-15
Published:
2024-05-05
Contact:
Cheng Yanli, Email: chengyanli0217@126.com
Supported by:
Shandong Province Natural Science Foundation Youth Project (ZR2020QH104)
Wnt信号通路在急性心肌梗死中的研究进展
杨寿娟1 张海涛2 崔明丽1 王建1 李洋1 程艳丽1
1滨州医学院附属医院心内科,滨州 256603;2滨州医学院附属医院神经外科,滨州 256603
通讯作者:
程艳丽,Email:chengyanli0217@126.com
基金资助:
山东省自然科学基金青年项目(ZR2020QH104)
Yang Shoujuan, Zhang Haitao, Cui Mingli, Wang Jian, Li Yang, Cheng Yanli.
Research progress of Wnt signaling pathway in acute myocardial infarction [J]. International Medicine and Health Guidance News, 2024, 30(8): 1291-1296.
杨寿娟 张海涛 崔明丽 王建 李洋 程艳丽.
Wnt信号通路在急性心肌梗死中的研究进展 [J]. 国际医药卫生导报, 2024, 30(8): 1291-1296.
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[1] van Zandvoort LJC, Otsuka K, Villiger M, et al. Polarimetric signatures of coronary thrombus in patients with acute coronary syndrome[J]. Circ J, 2021, 85(10):1806-1813. DOI: 10.1253/circj.CJ-20-0862. [2] Yasue H, Mizuno Y, Harada E. Coronary artery spasm - clinical features, pathogenesis and treatment[J]. Proc Jpn Acad Ser B Phys Biol Sci, 2019,95(2):53-66. DOI: 10.2183/pjab.95.005. [3] Sano T, Ito T, Ishigami S, et al. Intrinsic activation of cardiosphere-derived cells enhances myocardial repair[J]. J Thorac Cardiovasc Surg, 2022, 163(4):1479-1490.e5. DOI: 10.1016/j.jtcvs.2020.05.040. [4] Sun X, Malandraki-Miller S, Kennedy T, et al. The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development[J]. Development, 2021, 148(9):dev197525. DOI: 10.1242/dev.197525. [5] Haseeb M, Pirzada RH, Ain QU, et al. Wnt signaling in the regulation of immune cell and cancer therapeutics[J]. Cells, 2019, 8(11):1380. DOI: 10.3390/cells8111380. [6] 刘玉,冯立波.心肌梗死与Wnt信号通路的相关性研究现状[J].重庆医学,2017,46(6):845-848.DOI:10.3969/j.issn.1671-8348.2017.06.041. [7] Barandon L, Casassus F, Leroux L, et al. Secreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response[J]. Arterioscler Thromb Vasc Biol, 2011, 31(11):e80-e87. DOI: 10.1161/ATVBAHA.111.232280. [8] Morishita Y, Kobayashi K, Klyachko E, et al. Wnt11 gene therapy with adeno-associated virus 9 improves recovery from myocardial infarction by modulating the inflammatory response[J]. Sci Rep, 2016, 6:21705. DOI: 10.1038/srep21705. [9] Mizutani M, Wu JC, Nusse R. Fibrosis of the neonatal mouse heart after cryoinjury is accompanied by Wnt signaling activation and epicardial-to-mesenchymal transition[J]. J Am Heart Assoc, 2016, 5(3):e002457. DOI: 10.1161/JAHA.115.002457. [10] Wang J, Xia Y, Lu A, et al. Cardiomyocyte-specific deletion of β-catenin protects mouse hearts from ventricular arrhythmias after myocardial infarction[J]. Sci Rep, 2021, 11(1):17722. DOI: 10.1038/s41598-021-97176-9. [11] Liu Y, Neogi A, Mani A. The role of Wnt signalling in development of coronary artery disease and its risk factors[J]. Open Biol, 2020, 10(10):200128. DOI: 10.1098/rsob.200128. [12] Paik DT, Rai M, Ryzhov S, et al. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis[J]. Circ Res, 2015, 117(9):804-816. DOI: 10.1161/CIRCRESAHA.115.306886. [13] Palevski D, Levin-Kotler LP, Kain D, et al. Loss of macrophage Wnt secretion improves remodeling and function after myocardial infarction in mice[J]. J Am Heart Assoc, 2017, 6(1):e004387. DOI: 10.1161/JAHA.116. 004387. [14] Moon J, Zhou H, Zhang LS, et al. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist[J]. Proc Natl Acad Sci U S A, 2017, 114(7):1649-1654. DOI: 10.1073/pnas.1621346114. [15] Barandon L, Couffinhal T, Ezan J, et al. Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA[J]. Circulation, 2003, 108(18):2282-2289. DOI: 10.1161/01.CIR.0000093186.22847.4C. [16] 印纹源.分泌型卷曲相关蛋白1在心血管疾病中的研究进展[J].中国心血管病研究,2019,17(4):300-304.DOI:10.3969/j.issn.1672-5301.2019.04.003. [17] Tao J, Wang YT, Abudoukelimu M, et al. Association of genetic variations in the Wnt signaling pathway genes with myocardial infarction susceptibility in Chinese Han population[J]. Oncotarget, 2016, 7(33):52740-52750. DOI: 10.18632/oncotarget.10401. [18] Nakamura K, Sano S, Fuster JJ, et al. Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia/reperfusion injury[J]. J Biol Chem, 2016, 291(6):2566-2575. DOI: 10.1074/jbc.M115.693937. [19] Mirotsou M, Zhang Z, Deb A, et al. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair[J]. Proc Natl Acad Sci U S A, 2007, 104(5):1643-1648. DOI: 10.1073/pnas.0610024104. [20] Daskalopoulos EP, Blankesteijn WM. Effect of interventions in WNT signaling on healing of cardiac injury: a systematic review[J]. Cells, 2021, 10(2):207. DOI: 10.3390/cells10020207. [21] Guan H, Zhang J, Luan J, et al. Secreted frizzled related proteins in cardiovascular and metabolic diseases[J]. Front Endocrinol (Lausanne), 2021, 12:712217. DOI: 10.3389/fendo.2021.712217. [22] Yin C, Ye Z, Wu J, et al. Elevated Wnt2 and Wnt4 activate NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 following myocardial infarction[J]. EBioMedicine, 2021, 74:103745. DOI: 10.1016/j.ebiom.2021.103745. [23] Bovolenta P, Esteve P, Ruiz JM, et al. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease[J]. J Cell Sci, 2008, 121(Pt 6):737-746. DOI: 10.1242/jcs.026096. [24] Snead AN, Insel PA. Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts[J]. FASEB J, 2012, 26(11):4540-4547. DOI: 10.1096/fj.12-213496. [25] Chen L, Wu Q, Guo F, et al. Expression of Dishevelled-1 in wound healing after acute myocardial infarction: possible involvement in myofibroblast proliferation and migration[J]. J Cell Mol Med, 2004, 8(2):257-264. DOI: 10.1111/j.1582-4934.2004.tb00281.x. [26] Badimon L, Casaní L, Camino-Lopez S, et al. GSK3β inhibition and canonical Wnt signaling in mice hearts after myocardial ischemic damage[J]. PLoS One, 2019, 14(6):e0218098. DOI: 10.1371/journal.pone.0218098.. [27] Fu WB, Wang WE, Zeng CY. Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors[J]. Acta Pharmacol Sin, 2019, 40(1):9-12. DOI: 10.1038/s41401-018-0060-4. [28] Uitterdijk A, Hermans KC, de Wijs-Meijler DP, et al. UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine[J]. Lab Invest, 2016, 96(2):168-176. DOI: 10.1038/labinvest.2015.139. [29] Joiner DM, Ke J, Zhong Z, et al. LRP5 and LRP6 in development and disease[J]. Trends Endocrinol Metab, 2013, 24(1):31-39. DOI: 10.1016/j.tem.2012.10.003. [30] Ngo D, Sinha S, Shen D, et al. Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease[J]. Circulation, 2016, 134(4):270-285. DOI: 10.1161/CIRCULATIONAHA.116. 021803. [31] Borrell-Pages M, Vilahur G, Romero JC, et al. LRP5/canonical Wnt signalling and healing of ischemic myocardium[J]. Basic Res Cardiol, 2016, 111(6):67. DOI: 10.1007/s00395-016-0585-y. [32] Wo D, Peng J, Ren DN, et al. Opposing roles of Wnt inhibitors IGFBP-4 and Dkk1 in cardiac ischemia by differential targeting of LRP5/6 and β-catenin[J]. Circulation, 2016, 134(24):1991-2007. DOI: 10.1161/CIRCULATIONAHA.116.024441. [33] Li YH, Wu MH, Lee WJ, et al. A synergistic effect between plasma Dickkopf-1 and obstructive coronary artery disease on the prediction of major adverse cardiac events in patients with angina: an observational study[J]. Biomolecules, 2022, 12(10):1408. DOI: 10.3390/biom12101408. [34] Min JK, Park H, Choi HJ, et al. The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells[J]. J Clin Invest, 2011, 121(5):1882- 1893. DOI: 10.1172/JCI42556. [35] Sun HY, Wang XL, Ma LC, et al. Influence of MiR-154 on myocardial apoptosis in rats with acute myocardial infarction through Wnt/β-catenin signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23(2):818-825. DOI: 10.26355/eurrev_201901_16896. [36] Zhai CG, Xu YY, Tie YY, et al. DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways[J]. J Mol Cell Cardiol, 2018, 114:243-252. DOI: 10.1016/j.yjmcc. 2017.11.018. [37] Lal H, Ahmad F, Woodgett J, et al. The GSK-3 family as therapeutic target for myocardial diseases[J]. Circ Res, 2015, 116(1):138-149. DOI: 10.1161/CIRCRESAHA.116. 303613. [38] Tariq U, Uppulapu SK, Banerjee SK. Role of GSK-3 in cardiac health: focusing on cardiac remodeling and heart failure[J]. Curr Drug Targets, 2021, 22(13):1568-1576. DOI: 10.2174/1389450122666210224105430. [39] Wang D, Zhang Y, Ye T, et al. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway[J]. Int J Biol Sci, 2023, 19(4):1299-1315.DOI:10.7150/ijbs.79260. [40] Ahmad F, Marzook H, Gupta A, et al. GSK-3α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion[J]. J Mol Med (Berl), 2023, 101(11):1379-1396. DOI: 10.1007/s00109-023-02373-w. [41] Li YF, Wei TW, Fan Y, et al. Serine/threonine-protein kinase 3 facilitates myocardial repair after cardiac injury possibly through the glycogen synthase kinase-3β/β-catenin pathway[J]. J Am Heart Assoc, 2021, 10(22):e022802. DOI: 10.1161/JAHA.121.022802. [42] Thorne CA, Hanson AJ, Schneider J, et al. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α[J]. Nat Chem Biol, 2010, 6(11):829-836. DOI: 10.1038/nchembio.453. [43] Saraswati S, Alfaro MP, Thorne CA, et al. Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling[J]. PLoS One, 2010, 5(11):e15521. DOI: 10.1371/journal.pone.0015521. [44] Murakoshi M, Saiki K, Urayama K, et al. An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction[J]. PLoS One, 2013, 8(11):e79374. DOI: 10.1371/journal.pone.0079374. [45] Oerlemans MI, Goumans MJ, van Middelaar B, et al. Active Wnt signaling in response to cardiac injury[J]. Basic Res Cardiol, 2010, 105(5):631-641. DOI: 10.1007/s00395-010-0100-9. [46] Aisagbonhi O, Rai M, Ryzhov S, et al. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition[J]. Dis Model Mech, 2011, 4(4):469-483. DOI: 10.1242/dmm.006510. [47] Alvandi Z, Nagata Y, Passos LSA, et al. Wnt site signaling inhibitor secreted Frizzled-related protein 3 protects mitral valve endothelium from myocardial infarction-induced endothelial-to-mesenchymal transition[J]. J Am Heart Assoc, 2022, 11(7):e023695. DOI: 10.1161/JAHA.121.023695. [48] Matteucci M, Casieri V, Gabisonia K, et al. Magnetic resonance imaging of infarct-induced canonical wingless/integrated (Wnt)/β-catenin/T-cell factor pathway activation, in vivo[J]. Cardiovasc Res, 2016, 112(3):645-655. DOI: 10.1093/cvr/cvw214. [49] Wang W, Shang W, Zou J, et al. ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway[J]. Int J Mol Med, 2022, 50(4):129. DOI: 10.3892/ijmm.2022.5185. [50] Hahn JY, Cho HJ, Bae JW, et al. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts[J]. J Biol Chem, 2006, 281(41):30979-30989. DOI: 10.1074/jbc.M603916200. [51] Pang P, Qu Z, Yu S, et al. Mettl14 attenuates cardiac ischemia/reperfusion injury by regulating Wnt1/β-catenin signaling pathway[J]. Front Cell Dev Biol, 2021, 9:762853. DOI: 10.3389/fcell.2021.762853. [52] Xie S, Fu W, Yu G, et al. Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair[J]. J Mol Cell Biol, 2020, 12(1):42-54. DOI: 10.1093/jmcb/mjz023. [53] Sasaki T, Hwang H, Nguyen C, et al. The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium[J]. PLoS One, 2013, 8(9):e75010. DOI: 10.1371/journal.pone.0075010. [54] 李红艳,赵思涵,陈政,等.靶向Wnt信号通路在心肌梗死治疗中的研究进展[J].临床心血管病杂志,2020,36(5):479-484.DOI:10.13201/j.issn.1001-1439.2020.05.018. [55] Tang Y, Zhong Z, Wang X, et al. microRNA-497 inhibition mitigates myocardial infarction via enhancing wingless/integrated signal pathway in bone marrow mesenchymal stem cells[J]. J Cell Biochem, 2019, 120(8):13403-13412. DOI: 10.1002/jcb.28615. |
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