Abstract:

This article reported one case of ovarian cancer with paraneoplastic nephrotic syndrome (PNS) in Binzhou Medical University Hospital. The patient presented primarily with proteinuria, hematuria, and hypoalbuminemia. The positron emission tomography - computerized tomography (PET-CT) showed a mass in the left adnexa with multiple lymph node metastases in the abdominal and pelvic cavity. Lymph node biopsy pathology considered the possibility of high-grade serous carcinoma metastasis of the ovaries. Renal biopsy showed stage Ⅰ membranous nephropathy with focal globular sclerosis. After symptomatic treatment such as anti-infection, inducing diuresis to reduce edema, kidney protection, and urine protein reduction, the patient received neoadjuvant chemotherapy with paclitaxel and cisplatin for 4 cycles (paclitaxel 180 mg d1 and cisplatin 400 mg d1). There were no obvious abnormalities in blood routine and renal function tests, radical ovarian cancer was performed, and the recovery was good after surgery.

Key words:

Ovarian cancer, Paraneoplastic nephrotic syndrome, Membranous nephropathy

摘要：

本文报道滨州医学院附属医院1例以副肿瘤肾病综合征（PNS）为表现的卵巢癌患者。患者主要表现为蛋白尿、血尿及低白蛋白血症。正电子发射计算机断层显像（PET-CT）示：左附件区肿块伴腹腔盆腔多发淋巴结转移。淋巴结活检病理：考虑卵巢高级别浆液性癌转移可能性大。肾脏穿刺活检：膜性肾病Ⅰ期伴局灶球性硬化。在给予抗感染、利尿消肿、护肾、减少尿蛋白等对症治疗后，患者接受了紫杉醇联合顺铂新辅助化疗4个周期，具体剂量：紫杉醇180 mg d1、顺铂400 mg d1。复查血常规、肾功能等检查无明显异常，遂行卵巢癌根治术，术后恢复可。

关键词:

卵巢癌, 副肿瘤肾病综合征, 膜性肾病