Abstract: Objective　To observe the improved Kupperman score, constitution types of traditional Chinese medicine (TCM), and treatment methods of perimenopausal patients with breast cancer and the influence of TCM constitution types on Kupperman score. Methods　We conducted a cross-sectional survey on the perimenopausal patients with breast cancer treated at Breast Department, Guangdong Provincial Hospital of Chinese Medicine and The Second Clinical College, Guangzhou University of Chinese Medicine in 2015 by questionnaire. The questionnaire content included general information, the patients' diagnosis and treatment, TCM constitution types, and improved Kupperman score. We used descriptive statistical analysis, independent-sample t test, rank-sum test to observe the patients' common TCM constitution types and kupperman score, and to explore the effects of different treatment methods and TCM constitution types on kupperman score. Results　A total of 228 people were included in the survey, they were (52.50±4.75) years old. We found that the patients' TCM constitution types were often mixed; and the common constitution types were as below: blood stasis type (116 cases, 50.9%), qi stagnation type (110 cases, 48.2%), yang deficiency type (109 cases, 47.8%), and qi deficiency type (101 cases, 44.3%); 96.1% (219/228) of the patients had a Kupperman score over 6, 89.0% (203/228) had fatigue, 85.1% (194/228) had insomnia, and 85.1% (194/228) had emotional agitation. The Kupperman score was higher in the chemotherapy group than in the non-chemotherapy group (P=0.013). There were no statistical differences in the Kupperman score between the radiotherapy, endocrinological treatment, and targeted treatment. The total Kupperman score of the patients of normal constitution was lower than that of the patients without this constitution, while the total Kupperman scores of the patients with the other 7 types of constitutions except intrinsic constitution were higher than those in the patients without these constitutions, with statistical differences (all P<0.05). Conclusions　Blood stasis, qi stagnation, yang deficiency, and qi deficiency are the common constitution types of respondents. Perimenopausal syndrome occurs in most respondents. Chemotherapy can exacerbate perimenopausal symptoms. Normal constitution is a protective factor for the occurrence of perimenopausal syndrome, while the other seven constitutions except intrinsic constitution are the risk factors.

Key words: Breast cancer, Perimenopausal syndrome, TCM constitution types, Kupperman score

摘要： 目的　调查围绝经期乳腺癌患者的改良Kupperman评分情况、中医体质类型、肿瘤诊治方法以及体质对其Kupperman评分的影响。方法　通过调查问卷法对2015年在本院乳腺科就医的围绝经期乳腺癌患者进行横断面调查，问卷内容包含患者基本信息、诊治情况、体质以及改良Kupperman评分症状情况。应用描述性统计分析、独立样本t检验、秩和检验等方法，从而观察围绝经期乳腺癌患者的常见中医体质及其Kupperman评分情况，并探讨肿瘤治疗方式和体质与患者Kupperman评分的联系。结果　纳入228例，年龄（52.50±4.75）岁。被调查者体质常有兼夹，228例被调查者最常见的体质为血瘀质（116例，50.9%）、气郁质（110例，48.2%）、阳虚质（109例，47.8%）、气虚质（101例，44.3%）；96.1%（219/228）的受访者Kupperman评分>6分，89.0%（203/228）患者呈现疲乏，情绪激动和失眠（均85.1%，194/228）紧随其后；与未接受化疗的患者相比，化疗过的患者Kupperman评分程度更重（P=0.013）；而放疗、内分泌治疗、靶向治疗差异均无统计学意义（均P>0.05）；平和质Kupperman总分较其他体质的患者低，除了特禀质外其他7种偏颇体质则相反，差异均有统计学意义（均P<0.05）。结论　血瘀质、气郁质、阳虚质、气虚质为受访者常见体质；多数被调查者均出现了围绝经期症状，化疗则是患者症状加重的危险因素。从体质角度而言，受访者围绝经期综合征的保护性因素为平和质，而除了特禀质外7种偏颇体质则是危险因素。

关键词: 乳腺癌, 围绝经期综合征, 中医体质, Kupperman评分