Role of oxidative stress-related pathways in doxorubicin-induced cardiomyopathy

doi:10.3760/cma.j.issn.1007-1245.2024.20.005

Abstract

Abstract:

Doxorubicin (DOX) is a potent chemotherapy drug commonly used alone or in combination to treat a variety of cancers. However, its clinical application may lead to severe cardiotoxicity. Oxidative stress has been found to play an important role in doxorubicin-induced cardiomyopathy (DIC). This review summarizes the signaling pathways related to oxidative stress in DIC, including Nrf2/Keap1/ARE and Sirt1/p66Shc signaling pathways, and the roles of nitric oxide synthase (NOS), nitric oxide (NOX), and Fe²⁺ in oxidative stress, in an attempt to explain the mechanism of DIC from the perspective of oxidative stress and to provide a theoretical basis or a new way of thinking for the pharmacological research of DIC prevention and treatment.

Key words:

Doxorubicin, Cardiomyopathy, Oxidative stress, Signaling pathway, Review

摘要：

阿霉素（DOX）是一种强效化疗药物，常用于单独或联合治疗多种癌症，临床应用可能会导致严重的心脏毒性。氧化应激在阿霉素诱导心脏毒性（DIC）中发挥了重要作用。该综述总结了DIC中与氧化应激有关的信号通路，包括Nrf2/Keap1/ARE、Sirt1/p66Shc信号通路，以及一氧化氮合酶（NOS）、氮氧化物（NOX）、亚铁离子（Fe²⁺）在氧化应激中的作用，尝试从氧化应激的角度解释DIC的发生机制，并为DIC防治的药物研究提供理论依据或新思路。

关键词:

阿霉素, 心肌病, 氧化应激, 信号通路, 综述

Li Yang, Cheng Jinfeng, Wei Jingxun, Cui Mingli, Cheng Yanli.

Role of oxidative stress-related pathways in doxorubicin-induced cardiomyopathy [J]. International Medicine and Health Guidance News, 2024, 30(20): 3369-3372.

李洋程金凤魏景迅崔明丽程艳丽.

氧化应激相关通路在阿霉素诱导心脏毒性中的作用 [J]. 国际医药卫生导报, 2024, 30(20): 3369-3372.

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