Abstract:

Objective　To investigate the value of routine ultrasound combined with serum thyroglobulin antibody (TGAb) level in the diagnosis of Hashimoto's thyroiditis. Methods　A total of 86 patients with suspected Hashimoto's thyroiditis admitted to Liaocheng Third People's Hospital from March 2021 to October 2022 were selected, including 40 males and 46 females who were (41.67±3.35) years old, and the pathological diagnosis results were statistically analyzed (67 cases were pathologically diagnosed as Hashimoto's thyroiditis, and 19 cases non-Hashimoto thyroiditis). According to the pathological diagnosis results, they were divided into a Hashimoto's thyroiditis group and a non-Hashimoto's thyroiditis group. The routine ultrasound diagnosis of Hashimoto's thyroiditis was performed in both groups. The serum TGAb levels of the patients were detected. The diagnostic efficacies of routine ultrasound, serum TGAb level, and the combination in the diagnosis of Hashimoto's thyroiditis were compared. Multivariate logistic regression analysis was performed to analyze the diagnostic values of TGAb level and leopard pattern for Hashimoto's thyroiditis by receiver operating characteristic curve (ROC). Results　The leopard pattern in routine ultrasound and TGAb level in the Hashimoto's thyroiditis group were higher than those in the non-Hashimoto's thyroiditis group [53.73% (36/67) vs. 26.32% (5/19) and (83.25±8.14) IU/ml vs. (46.34±6.27) IU/ml; both P<0.05]. The multivariate analysis results showed that the TGAb level was correlated with the diagnosis of Hashimoto's thyroiditis (OR=3.615, P<0.05). The areas under the curves (AUC) of the routine ultrasound, TGAb level, and combination in the diagnosis of Hashimoto's thyroiditis were 0.756, 0.706, and 0.838; the specificities were 57.9%, 63.2%, and 84.2%; the sensitivities were 86.6%, 71.6%, and 89.6%. The diagnostic efficacy of the combination was better than those of the single examinations. Conclusion　conventional ultrasound and serum TGAb level both have certain value in the diagnosis of Hashimoto's thyroiditis, but the combination has higher diagnostic value, and can provide reliable basis for the clinical diagnosis.

Key words:

Hashimoto's thyroiditis, Routine ultrasound, Serum thyroglobulin antibody, Diagnostic value, Pathological diagnosis

摘要：

目的　探讨常规超声联合血清甲状腺球蛋白抗体（anti-thyroglobulin antibodies，TGAb）水平对桥本甲状腺炎的诊断价值。方法　选取2021年3月至2022年10月聊城市第三人民医院收治的86例疑似桥本甲状腺炎患者［男40例、女46例，年龄（41.67±3.35）岁，统计病理学诊断结果（经病理诊断为桥本甲状腺炎67例，非桥本甲状腺炎19例）］，根据病理诊断结果分为桥本甲状腺炎组和非桥本甲状腺炎组，均行常规超声诊断桥本甲状腺炎。检测患者血清TGAb水平，比较常规超声、血清TGAb水平及联合诊断桥本甲状腺炎的效能。采用logistic回归进行多因素分析，以受试者工作特征曲线（receiver operating characteristic curve，ROC）分析TGAb水平、豹纹状对桥本甲状腺炎的诊断价值。结果　桥本甲状腺炎组常规超声中豹纹状及TGAb水平高于非桥本甲状腺炎组［53.73%（36/67）比26.32%（5/19）、（83.25±8.14）IU/ml比（46.34±6.27）IU/ml，均P<0.05］。多因素分析结果显示，TGAb水平与患者桥本甲状腺炎诊断相关（OR=3.615，P<0.05）。常规超声、TGAb水平及联合诊断桥本甲状腺炎的曲线下面积（area under the curve，AUC）分别为0.756、0.706、0.838，特异度分别为57.9%、63.2%、84.2%，灵敏度分别为86.6%、71.6%、89.6%，常规超声联合TGAb水平诊断效能优于单独检查。结论　常规超声、血清TGAb水平对桥本甲状腺炎均有一定的诊断价值，但联合的诊断价值更高，可为临床诊断提供可靠的依据。

关键词:

桥本甲状腺炎, 常规超声, 血清甲状腺球蛋白抗体, 诊断价值, 病理诊断