Abstract:

Objective　To study the effect of pulmonary function monitoring combined with exercise for weight loss on symptom control in children with cough-variant asthma. Methods　A total of 100 children with cough variant asthma admitted to Shaoguan Maternal and Child Health  Care Hospital from January 2020 to January 2023 were divided into an observation group and a control group, with 50 cases in each group. In the observation group, there were 23 boys and 27 girls, aged 5-12 (8.09±1.14) years. In the control group, there were 28 boys and 22 girls, aged 5-12 (7.89±1.54) years. The control group was treated routinely, and the observation group was treated with pulmonary function monitoring and exercise for weight loss on the basis. The clinical efficacy, symptom score, pulmonary function indexes, inflammatory factors, and prognosis of the two groups were evaluated. Independent sample t test and χ² test were used. Results　The total effective rate of the observation group was 92.00% (46/50), which was higher than that of the control group [74.00% (37/50)] (χ²=5.741, P=0.017). After treatment, the forced expiratory volume in the first second (FEV1), peak-to-volume ratio (VPEF/VE), and peak-to-time ratio (TPTEF/TE) in the observation group were higher than those in the control group (all P<0.05). After treatment, the scores of cough, nasal congestion, dry and itchy pharynx, and chest tightness and shortness of breath in the observation group were lower than those in the control group (all P<0.05). After treatment, the levels of inflammatory factors [hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α)] in the observation group were lower than those in the control group (all P<0.05). After treatment, the score of St. George's Respiratory Questionnaire (SGRQ) and Borg dyspnea score in the observation group were lower than those in the control group, and the 6-min walking distance (6MWD) was higher than that in the control group (all P<0.05). Conclusion　Pulmonary function monitoring combined with exercise for weight loss is a good intervention for children with cough variant asthma, which can control the children's symptoms, improve the lung function, reduce the levels of inflammatory factors, and promote the rehabilitation.

Key words:

Cough variant asthma, Pulmonary function monitoring, Exercise for weight loss, Symptom control, Inflammatory factors, Children

摘要：

目的　探讨肺功能监测联合运动减肥对咳嗽变异性哮喘患儿症状控制的影响。方法　选取2020年1月至2023年1月韶关市妇幼保健院收治的100例咳嗽变异性哮喘患儿分为观察组、对照组，每组50例。观察组：男性23例、女性27例，年龄5～12（8.09±1.14）岁；对照组：男性28例、女性22例，年龄5～12（7.89±1.54）岁。对照组行常规治疗，观察组在此基础上实施肺功能监测联合运动减肥干预。评估两组临床疗效、症状评分、肺功能指标、炎症因子、预后康复效果。采用独立样本t检验、χ²检验。结果　观察组总有效率为92.00%（46/50），高于对照组的74.00%（37/50）（χ²=5.741，P=0.017）。治疗后，观察组第1秒用力呼气容积（FEV1）、达峰容积比（VPEF/VE）、达峰时间比（TPTEF/TE）均高于对照组（均P<0.05）。治疗后，观察组咳嗽、鼻塞、咽干咽痒、胸闷急促评分均低于对照组（均P<0.05）。治疗后，观察组炎症因子［超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）］水平均低于对照组（均P<0.05）。治疗后，观察组圣乔治呼吸问卷（SGRQ）评分、Borg呼吸困难评分均低于对照组，6 min步行距离（6MWD）高于对照组（均P<0.05）。结论　肺功能监测联合运动减肥对咳嗽变异性哮喘患儿干预效果良好，控制患儿症状，提高肺功能，降低炎症因子水平，促进康复。

关键词:

咳嗽变异性哮喘, 肺功能监测, 运动减肥, 症状控制, 炎症因子, 儿童