Experimental research progress of metformin in spinal cord injury

doi:10.3760/cma.j.issn.1007-1245.2023.15.003

Abstract

Abstract:

Spinal cord injury is a devastating disease, which can destroy the anatomical structure of the spinal cord, cause a series of pathological reactions such as axon rupture, neuronal degeneration and necrosis, inflammation, demyelination, etc., and eventually lead to severe neurological dysfunction, seriously affecting the patients' quality of life. Metformin, a classic antidiabetic drug and antioxidant, has been extended to experimental treatment of spinal cord injury as a representative of new use of old drugs. This paper retrospectively analyzes the relevant literature reports in order to improve the understanding on metformin in spinal cord injury.

Key words:

Spinal cord injury, Metformin, Regulation, Progress

摘要：

脊髓损伤是一种毁灭性的疾病，可破坏脊髓解剖结构，引起轴突断裂、神经元变性坏死、炎性反应、脱髓鞘形成等一系列病理反应，最终导致严重的神经功能障碍，严重影响患者生活质量。二甲双胍是一种经典的抗糖尿病药物和抗氧化剂，作为老药新用的代表，已将其应用扩展到实验性脊髓损伤治疗。本文对相关文献报道进行了回顾性分析，以期提高二甲双胍在脊髓损伤方面的认识。

关键词:

脊髓损伤, 二甲双胍, 炎性反应, 进展

Dong Jinyu, Gong Xingyuan, Ma Yue, Hu Zhongbo, Liu Sheng, Liu Yongliang.

Experimental research progress of metformin in spinal cord injury [J]. International Medicine and Health Guidance News, 2023, 29(15): 2081-2085.

董金玉龚星源马跃胡忠波刘晟刘永良.

二甲双胍在脊髓损伤中的实验性研究进展 [J]. 国际医药卫生导报, 2023, 29(15): 2081-2085.

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