Abstract:

Objective　To explore the memory changes in patients with chronic obstructive pulmonary disease (COPD) during 1 year follow-up and the correlation of memory with lung function, arterial partial pressure of oxygen (PaO₂), arterial partial pressure of CO₂ (PaCO₂), and haemoglobin (Hb). Methods　This was a prospective cohort study. The subjects were divided into a healthy control (HC) group and a COPD group. During the 1 year follow-up, the data of 72 cases in the HC group were collected; the data of 89 cases in the COPD group were collected. Both groups were tested for memory function at entry and at 1 year of followed-up using the Digit Span-Reversed Order (DS-RO) and the Chinese Auditory Verbal Learning Test (CAVLT). Pulmonary function was measured at the time of enrollment and at 1 year of follow-up, including forced vital capacity (FVC), forced expiratory volume in the first second (FEV₁), and FEV₁/FVC. The PaCO₂, PaO₂, and Hb of the COPD patients were detected at the time of enrollment and at 1 year of follow-up. t, χ², and U tests were applied. Results　At the time of enrollment and at 1 year of follow-up, the scores of DS-RO [(6.21±0.94 vs. (6.54±1.08) and (6.02±0.91) vs. (6.44±1.06)] and CAVLT instantaneous recall [(8.12±1.23) vs. (8.58±1.46) and (7.86±1.18) vs. (8.43±1.43)] in the COPD group were lower than those in the HC group, with statistical differences (t=2.07, 2.70, 2.17, and 2.88; all P<0.05). The changes of DS-RO and CAVLT instantaneous recall between 1 year follow-up and enrollment were positively correlated with PaO₂ (r=0.480 and 0.362) and Hb (r=0.327 and 0.231). Conclusions　The differences between COPD patients and healthy adults in delayed memory and long term memory are small. COPD patients show a decrease in transient memory function. There are positive correlations of transient memory function with PaO₂ and Hb: the more significant the decrease in PaO₂ and Hb, the more severe the decrease in transient memory in COPD patients.

Key words:

Chronic obstructive pulmonary disease, Memory, Lung function, Blood gas, Changes

摘要：

目的　探讨慢性阻塞性肺疾病（COPD）受试者随访1年记忆力变化及记忆力和肺功能、动脉血氧分压（PaO₂）、动脉血二氧化碳分压（PaCO₂）、血红蛋白（Hb）的相关性。方法　本研究为前瞻性队列研究，受试者为无锡市第二人民医院2021年2月至2021年7月接收的COPD患者（COPD组）和健康体检者（HC组），受试者在2022年2月至7月接受1次随访评测。在1年的随访时间内，HC组共72例完成研究所需资料收集，COPD组共89例完成资料收集，采用数字广度‐倒背（DS‐RO）及中文听觉词语学习测试（CAVLT）测试2组受试者入组时及随访1年的记忆功能，并检测COPD患者入组时及随访1年肺功能状况：用力肺活量（FVC）及第1秒用力呼气量（FEV₁），计算FEV₁/FVC；检测COPD患者入组时及随访1年的PaCO₂、PaO₂、Hb。统计学方法采用t检验、χ²检验、U检验。结果　COPD组受试者入组时、随访1年的DS‐RO［（6.21±0.94）分比（6.54±1.08）分、（6.02±0.91）分比（6.44±1.06）分］及CAVLT瞬时回忆［（8.12±1.23）分比（8.58±1.46）分、（7.86±1.18）分比（8.43±1.43）分］得分均低于HC组同期，差异均有统计学意义（t=2.07、2.70、2.17、2.88，均P<0.05）；COPD患者随访1年与入组时的DS‐RO变化、CAVLT瞬时回忆变化与PaO₂变化（r=0.480、0.362）、Hb变化（r=0.327、0.231）呈正相关性。结论　COPD患者与健康成人在延时记忆、长时记忆差异较小，COPD患者表现为瞬时记忆功能下降，瞬时记忆功能和PaO₂、Hb呈正相关性，PaO₂、Hb下降越明显，COPD患者的瞬时记忆下降越严重。

关键词:

慢性阻塞性肺疾病, 记忆, 肺功能, 血气, 变化