Abstract: Objective　To observe, evaluate, and analyze the clinical effect of amlodipine besylate combined with Jiangya Tiaozhi decoction in the treatment of hypertension complicated with hyperlipidemia. Methods　A total of 98 patients with hypertension and hyperlipidemia admitted to Community Health Service Center of Lishui Town, Nanhai District, Foshan City from January 2019 to January 2020 were simply randomly divided into two groups. In the control group, there were 29 males and 20 females, aged (59.15±8.97) years; there were 28 males and 21 females in the observation group, aged (58.69±8.73) years. The control group was treated with amlodipine besylate, and the observation group was treated with Jiangya Tiaozhi decoction on the basis of the control group. The clinical effects, heart rates and levels of systolic blood pressure, diastolic blood pressure, and blood lipids before treatment and after 12 weeks of treatment were compared between the two groups. t test and χ² test were used for statistical analysis. Results　The total effective rate of the observation group was significantly higher than that of the control group [97.96% (48/49) vs. 77.55% (38/49)], with a statistically significant difference between the two groups (χ²=9.496 1, P=0.002 1). After 12 weeks of treatment, the heart rate, systolic blood pressure, and diastolic blood pressure in the two groups were significantly lower than those before treatment (all P<0.05), and the heart rate, systolic blood pressure, and diastolic blood pressure in the observation group were significantly lower than those in the control group (t=4.742 6, 7.727 3, and 4.953 2; all P<0.000 1). After 12 weeks of treatment, the levels of triglyceride (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C) in both groups were lower than those before treatment (all P<0.05), and those in the observation group were significantly lower than those in the control group (t=3.293 5, 4.725 3, and 5.673 4; all P<0.000 1). The levels of high density lipoprotein cholesterol (HDL-C) in the two groups after 12 weeks of treatment were higher than those before treatment (both P<0.05), and that in the observation group was significantly higher than that in the control group (t=4.250 3, P<0.000 1). Conclusion　Amlodipine besylate combined with traditional Chinese medicine in the treatment of hypertension with hyperlipidemia can significantly improve the clinical efficacy, effectively improve the patients' blood pressure and blood lipids, worthy of promotion and application in grassroots community health service centers.

Key words: Hypertension, Hyperlipidemia, Amlodipine besylate, Jiangya Tiaozhi decoction

摘要： 目的　观察评价分析苯磺酸氨氯地平片联合降压调脂汤剂治疗高血压合并高血脂的临床效果。方法　选择2019年1月至2020年1月期间佛山市南海区里水镇社区卫生服务中心收治的高血压合并高血脂患者98例，简单随机分为两组。对照组男29例，女20例，年龄（59.15±8.97）岁；观察组男28例，女21例，年龄（58.69±8.73）岁。对照组给予苯磺酸氨氯地平治疗；观察组在对照组基础上给予降压调脂汤剂治疗。比较两组患者的临床效果，治疗前、治疗12周后心率、收缩压、舒张压及血脂水平。统计学方法采用t检验、χ²检验。结果　观察组患者的总有效率明显高于对照组［97.96%（48/49）比77.55%（38/49）］，两组比较差异有统计学意义（χ²=9.496 1，P=0.002 1）。两组治疗12周后心率、收缩压及舒张压较治疗前均明显降低（均P<0.05），观察组治疗12周后心率、收缩压及舒张压均明显低于对照组（t=4.742 6、7.727 3、4.953 2，均P<0.000 1）。两组治疗12周后三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）水平均低于治疗前（均P<0.05），且观察组均显著低于对照组（t=3.293 5、4.725 3、5.673 4，均P<0.000 1）；两组治疗12周后高密度脂蛋白胆固醇（HDL-C）水平高于治疗前（均P<0.05），且观察组明显高于对照组（t=4.250 3，P<0.000 1）。结论　运用苯磺酸氨氯地平片联合中药治疗高血压合并高血脂可以显著地提高临床疗效，能够有效地改善患者的血压和血脂情况，值得基层社区卫生服务中心大力推广应用。

关键词: 高血压, 高血脂, 苯磺酸氨氯地平, 降压调脂汤剂