关键词:

肺癌, 运动干预, 生活质量, meta分析

Abstract:

Objective　To systematically evaluate the effect of exercise interventions on health-related quality of life in patients with lung cancer. Methods　A literature search was conducted on PubMed, Embase, Cochrane library, Wanfang, and CNKI databases until March 2024 for randomized controlled trials about effect of exercise interventions on health-related quality of life in patients with lung cancer. Data from studies meeting the inclusion criteria were extracted, and a meta-analysis was performed using STATA software. Results　A total of 12 trials involving 333 patients were included. The results of meta-analysis showed that exercise interventions improved the overall health status/quality of life [weighted mean difference (WMD) =6.70, 95% confidence interval (CI): 2.49, 10.90, P=0.002] and physical function (WMD=1.78, 95%CI: 0.22, 3.33, P=0.025) of lung cancer patients, ameliorated dyspnea (WMD=-5.65, 95%CI: -8.62, -2.68, P<0.001) and pain symptoms (WMD=-8.26, 95%CI: -14.66, -1.87, P=0.011), but had no significant effect on patients' fatigue (WMD=-4.04, 95%CI: -8.76, 0.69, P=0.094). Conclusion　Exercise interventions can effectively improve the health-related quality of life in patients with lung cancer, and more randomized controlled trials are needed to confirm these findings.

Key words:

Lung cancer, Exercise interventions, Quality of life, Meta analysis