胸部CT联合肿瘤标志物诊断宫颈癌合并肺转移的价值

doi:10.3760/cma.j.cn441417-20240101-16026

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (16): 2770-2774.DOI: 10.3760/cma.j.cn441417-20240101-16026

胸部CT联合肿瘤标志物诊断宫颈癌合并肺转移的价值

张丽¹ 王海娥² 胡云峰³

¹榆林市中医医院检验科，榆林 719000；²榆林市第一医院呼吸与危重症医学科，榆林 718000；³延安大学附属医院肿瘤科，延安 716000

收稿日期:2025-02-08 出版日期:2025-08-15 发布日期:2025-08-28
通讯作者: 王海娥，Email：17868823164@163.com
基金资助:
陕西省教育厅专项科研计划（18JK0864）

Value of chest CT combined with tumor markers for cervical cancer complicated with lung metastasis

Zhang Li¹, Wang Hai'e², Hu Yunfeng³

¹Department of Laboratory Medicine, Yulin Hospital of Traditional Chinese Medicine, Yulin 719000, China; ²Department of Respiratory and Critical Care Medicine, Yulin First Hospital, Yulin 718000, China; ³Department of Oncology, Yan'an University Affiliated Hospital, Yan'an 716000, China

Received:2025-02-08 Online:2025-08-15 Published:2025-08-28
Contact: Wang Hai'e, Email: 17868823164@163.com
Supported by:
Special Scientific Research Plan of Shaanxi Education Department (18JK0864)

摘要/Abstract

摘要：

目的　探讨胸部CT联合血清甲胎蛋白（AFP）、癌胚抗原（CEA）、鳞状细胞癌抗原（SCC-Ag）等肿瘤标志物诊断宫颈癌合并肺转移的价值。方法　选取2020年1月至2024年12月于榆林市中医医院就诊的280例宫颈癌患者为研究对象。根据是否合并肺转移分为转移组（15例）和非转移组（265例）。转移组年龄（45.73±6.24）岁；非转移组年龄（46.31±5.76）岁。所有患者均行胸部CT检查，记录其肺部是否存在结节、肿块、斑片状影、胸腔积液等异常征象。同时，检测血清AFP、CEA、SCC-Ag水平。绘制受试者操作特征曲线（ROC），计算曲线下面积（AUC），分析各指标单独及联合诊断宫颈癌合并肺转移的效能。采用t检验、χ²检验进行统计分析。结果　转移组胸部CT呈现结节、肿块、斑片状影、胸腔积液等异常征象的比例及AFP、CEA、SCC-Ag水平均高于非转移组（均P<0.05）。ROC分析结果显示，各指标单独诊断宫颈癌合并肺转移AUC依次为SCC-Ag（0.796）、CEA（0.781）、AFP（0.767）、肺部结节（0.753）、胸腔积液（0.681）、肺部肿块（0.644）、斑片状影（0.599）；各指标联合诊断宫颈癌合并肺转移的AUC为0.925。结论　胸部CT联合血清AFP、CEA、SCC-Ag能有效提高宫颈癌合并肺转移的诊断准确性，可为临床诊断提供有力支撑。

关键词:

胸部CT, 甲胎蛋白, 癌胚抗原, 鳞状细胞癌抗原, 宫颈癌, 肺转移, 诊断价值

Abstract:

Objective　To explore the diagnostic value of chest CT combined with serum tumor markers [alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC-Ag)] for cervical cancer complicated with lung metastasis. Methods　A total of 280 patients with cervical cancer treated in Yulin Hospital of Traditional Chinese Medicine between January 2020 and December 2024 were selected as the study objects. According to the presence or absence of lung metastasis, they were divided into a metastasis group [15 cases; (45.73±6.24) years old] and a non-metastasis group [265 cases; (46.31±5.76) years old]. All the patients underwent chest CT examination, and the abnormal signs (lung nodules, lumps, patchy shadow, and pleural effusion) were recorded. The serum levels of AFP, CEA, and SCC-Ag were detected. The diagnostic efficacies of each indicator and the combined detection for cervical cancer complicated with lung metastasis were analyzed by the receiver operating characteristic curve (ROC) and area under the curve (AUC). t test and χ² test were used for the statistical analysis. Results　The proportions of the abnormal chest CT signs (nodules, lumps, patchy shadow, and pleural effusion) and levels of AFP, CEA, and SCC-Ag in the metastasis group were higher than those in the non-metastasis group (all P<0.05). The results of ROC analysis showed that AUC's of SCC-Ag, CEA, AFP, lung nodule, pleural effusion, lung lump, patchy shadow, and their combination in the diagnosis of cervical cancer complicated with lung metastasis were 0.796, 0.781, 0.767, 0.753, 0.681, 0.644, 0.599, and 0.925, respectively. Conclusion　Chest CT combined with serum AFP, CEA, and SCC-Ag can effectively improve the diagnostic accuracy for cervical cancer complicated with lung metastasis, and provide strong support for clinical diagnosis.

Key words:

Chest CT, Alpha-fetoprotein, Carcinoembryonic antigen, Squamous cell carcinoma antigen, Cervical cancer, Lung metastasis, , Diagnostic value

张丽王海娥胡云峰.

胸部CT联合肿瘤标志物诊断宫颈癌合并肺转移的价值 [J]. 国际医药卫生导报, 2025, 31(16): 2770-2774.

Zhang Li, Wang Hai'e, Hu Yunfeng.

Value of chest CT combined with tumor markers for cervical cancer complicated with lung metastasis [J]. International Medicine and Health Guidance News, 2025, 31(16): 2770-2774.

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胸部CT联合肿瘤标志物诊断宫颈癌合并肺转移的价值

Value of chest CT combined with tumor markers for cervical cancer complicated with lung metastasis

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