膳食炎症指数与结直肠癌及其癌变病变的研究进展

doi:10.3760/cma.j.cn441417-20241218-10008

摘要/Abstract

摘要：

结直肠癌（colorectal cancer，CRC）是常见消化系统恶性肿瘤及全球癌症死亡的第二大原因。结直肠腺瘤性息肉（colorectal adenomatous polyps，CAP）为其癌前病变。慢性炎症通过诱导DNA损伤和基因突变、破坏肠道菌群稳态等在CRC和CAP发生发展中起重要作用。膳食模式与之密切相关。促炎饮食能够提高机体内的慢性炎症水平，抗炎饮食则降之。国内外研究表明，高膳食炎症指数（dietary inflammatory index，DII）与CRC风险增高相关，而在CAP方面，两者之间的研究结论并不一致。本文综述了现有的CRC及其癌前病变与DII之间的相关研究现状，旨在为简化DII以制订个性化饮食干预方案以及CRC及其癌前病变的预防与治疗提供一定的理论依据。

关键词: 结直肠癌, , , 结直肠息肉, , , 膳食炎症指数, , , 预防, , , 进展

Abstract:

Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive system and the second leading cause of cancer-related mortality worldwide. Colorectal adenomatous polyps (CAP) serve as precursors to this malignancy. Chronic inflammation significantly contributes to the onset and progression of CRC and CAP inducing DNA damage and gene mutations, as well as disrupting the homeostasis of gut microbiota. Dietary patterns are closely linked to this process; pro-inflammatory diets elevate levels of chronic inflammation, while anti-inflammatory diets mitigate them. Researches conducted both domestically and internationally have demonstrated that a high dietary inflammatory index (DII) correlates with increased risk of CRC; however, the relationship between DII and CAP remains inconsistent. This article reviews the current state of researches on the association between colorectal cancer, its precursors, and DII, with the aim of providing theoretical foundation for simplifying DII to develop personalized dietary intervention strategies, thereby enhancing the prevention and treatment of CRC and its precursors.

Key words: , Colorectal cancer, , Colorectal polyps, , Dietary inflammatory index, , Prevention, , Progress

秦振昆邓冬燕冯晓玲. 膳食炎症指数与结直肠癌及其癌变病变的研究进展 [J]. 国际医药卫生导报, 2025, 31(10): 1624-1627.

Qin Zhenkun, Deng Dongyan, Feng Xiaoling.

Research progress of dietary inflammatory index and colorectal cancer and its precancerous lesions [J]. International Medicine and Health Guidance News, 2025, 31(10): 1624-1627.

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