关键词:

冠状动脉钙化, 冠状动脉钙化积分, 三酰甘油葡萄糖乘积指数, 三酰甘油, 空腹血糖, 危险因素

Abstract:

Objective　To analyze the relationship between serum triglyceride-glucose index (TyG index) and coronary artery calcification (CAC), and investigate the risk factors of CAC. Methods　A retrospective analysis was performed on 399 subjects who underwent coronary angiography with chest tightness or chest pain as the main complaint in the Department of Cardiology, Baoji Central Hospital from January 2022 to January 2024. Among them, there were 192 males and 207 females, aged (66.35±11.48) years. The patients were divided into a CAC group (245 cases) and a non-CAC group (154 cases) according to the presence or absence of CAC. The differences of clinical indicators were compared between the two groups, the influencing factors of CAC were evaluated by binary logistic regression analysis, and the diagnostic value of TyG index and other indicators for CAC was evaluated by the receiver operating characteristic curve (ROC). Independent sample t test, rank sum test, χ² test, and Spearman correlation analysis were used for statistical analysis. Results　The age, triglyceride (TG), fasting blood glucose (FBG), serum creatinine, uric acid, N-terminal brain natriuretic peptide precursor (NT-proBNP), D-dimer, TyG index, and male and smoking ratios in the CAC group were all higher than those in the non-CAC group, while the high-density lipoprotein cholesterol (HDL-C) and diastolic blood pressure in the CAC group were lower than those in the non-CAC group, with statistically significant differences (all P<0.05). Spearman correlation analysis showed that CAC was positively correlated with age, TyG index, and uric acid, and was negatively correlated with HDL-C (r=0.424, 0.151, 0.196, and -0.152, all P<0.05). Binary logistic regression analysis showed that age (OR=1.087, 95%CI 1.064-1.111, P<0.001), male (OR=1.830, 95%CI 1.215-2.757, P=0.004), TG (OR=1.364, 95%CI 1.071-1.739, P=0.012), FBG (OR=1.191, 95%CI 1.079-1.314, P=0.001), TyG index (OR=1.589, 95%CI 1.177-2.145, P=0.002), serum creatinine (OR=1.018, 95%CI 1.009-1.028, P<0.001), and uric acid (OR=1.003, 95%CI 1.001-1.005, P=0.001) were independent risk factors for CAC, while HDL-C (OR=0.546, 95%CI 0.399-0.880, P=0.013) was a protective factor. ROC analysis showed that the area under the curve of TyG index combined with age was the largest [0.753 (95%CI 0.704-0.802), P<0.001]. Conclusion　Age, male, TG, FBG, TyG index, serum creatinine, and uric acid are independent risk factors for CAC, and TyG index combined with age has good diagnostic value for CAC.

Key words:

Coronary artery calcification, Coronary artery calcification score, Triglyceride-glucose index, Triglyceride, Fasting blood glucose, Risk factors