国际医药卫生导报 ›› 2022, Vol. 28 ›› Issue (6): 822-824.DOI: 10.3760/cma.j.issn.1007-1245.2022.06.022

• 儿科专栏 • 上一篇    下一篇

生物制剂治疗儿童风湿性疾病的进展

张冰 刘力   

  1. 天津市儿童医院(天津大学儿童医院)综合内科(免疫),天津 300074
  • 收稿日期:2022-01-07 出版日期:2022-03-15 发布日期:2022-04-15
  • 通讯作者: 刘力,Email:may13_cn@126.com

Progress on biological agents in the treatment of pediatric rheumatic diseases

Zhang Bing, Liu Li   

  1. Department of General Internal Medicine (Immunology), Tianjin Children's Hospital (Children's Hospital of Tianjin University), Tianjin 300074, China

  • Received:2022-01-07 Online:2022-03-15 Published:2022-04-15
  • Contact: Liu Li, Email: may13_cn@126.com

摘要: 近十几年来,生物制剂被广泛应用于儿童风湿性疾病的治疗,并取得很好的疗效,但是在国内外获批的适应证并不相同,儿童适应证较少。根据药物作用机制不同,可以将生物制剂分为针对细胞因子类、针对B细胞类、针对T细胞类和针对细胞信号转导类。本文将生物制剂按照上述4个类型进行总结归纳,介绍作用机制和适应证。

关键词: 生物制剂, 风湿性疾病, 儿童, 适应证

Abstract: In recent decades, biological agents have been widely used in the treatment of rheumatic diseases in children and have achieved good therapeutic effects. However, the indications approved are different in China and at abroad, and there are fewer approved indications for children. According to the different mechanisms of drug, biological agents can be divided into four types: for cytokines, for B cells, for T cells, and for signal transduction. In this paper, the mechanisms of action and indications of biological agents are summarized according to the above four types.

Key words: Biological agents, Rheumatic diseases, Children, Indications