人结直肠锯齿状腺癌的研究现状

doi:10.3760/cma.j.issn.1007-1245.2022.13.007

摘要/Abstract

摘要： 结直肠锯齿状腺癌（serrated adenocarcinoma，SAC）作为大肠癌的一种特殊临床类型，因其癌变途径的特殊性，检测以及较差的治疗反应和预后逐渐引起众多研究者的兴趣。其产生的途径主要为“锯齿状通路”途径，锯齿状通路途径以BRAF突变、微卫星体不稳定（microsatellite instability，MSI））和CpG岛的甲基化（CpG island methylator phenotype，CIMP）为特征。由于特殊的形态和内镜特征及特殊的发生部位，在结肠镜检查时很容易漏诊，甚至病理评估时也极易被忽视，临床确诊时往往已处于进展期，患者预后差，生存率低。本文针对锯齿状结直肠腺癌流行病学、危险因素、临床特征、病理学特征、分子特征等作一综述。

关键词: 锯齿状腺癌, 流行病学, 危险因素, 临床特征, 病理学特征, 分子特征

Abstract:

As a special clinical type of colorectal cancer, serrated adenocarcinoma (SAC) has attracted the interest of many researchers due to its special carcinogenesis pathway, poor detection, and poor treatment response and prognosis. The serrated pathway is characterized by BRAF mutation, microsatellite instability (MSI), and CpG island methylator phenotype (CIMP). Due to the special morphology, endoscopic characteristics, and occurrence site, it is easy to be missed during colonoscopy, and even easily ignored during pathological evaluation. When it is clinically diagnosed, the patients are often in the advanced stage, with poor prognosis and a low survival rate. This article reviews the epidemiology, risk factors, and clinical, pathological and molecular features of serrated colorectal adenocarcinoma.

Key words: Serrated colorectal adenocarcinoma, Epidemiology, Risk factors, Clinical features, Pathological features, Molecular features

王娜　贾兴芳　储琳琳　郝佳慧　刘成霞. 人结直肠锯齿状腺癌的研究现状[J]. 国际医药卫生导报, 2022, 28(13): 1810-1814.

Wang Na, Jia Xingfang, Chu Linlin, Hao Jiahui, Liu Chengxia. Research progress of colorectal serrated adenocarcinoma of human [J]. International Medicine and Health Guidance News, 2022, 28(13): 1810-1814.

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