关键词:

鼻咽癌, 芦荟, 敛疮生肌膏, 放射性皮炎, 临床研究

Abstract:

Objective　To evaluate the efficacy and safety of aloe and Lianchuang Shenji ointment for nasopharyngeal carcinoma patients with radiation dermatitis. Methods　Ninety-six nasopharyngeal carcinoma patients with radiation dermatitis treated at Department of Radiotherapy, Yulin Hospital, First Hospital, Xi'an Jiaotong University from January 2020 to May 2023 were selected for the randomized controlled trial, and were divided into a control group and a study group by the random number table method, with 48 cases in each group. There were 23 males and 25 females in the control group; they were (52.84±9.41) years old. There were 26 males and 22 females in the study group; they were (53.66±8.57) years old. The control group took routine treatment. The study group were treated with aloe and Lianchuang Shenji ointment. The radiation dermatitis grades (RTOG), treatment effects, scores of acute radiation dermatitis response (RISRAS), pain scores of Numerical Rating Scale (NRS), scores of Karnofsky Performance Status (KPS), and serum levels of interleukin-6 (IL-6) and C-reaction protein (CRP), before and after the treatment and incidences of adverse reactions were compared between the two groups by t and χ² tests. Results　The total effective rate in the study group was higher than that in the control group [93.8% (45/48) vs. 72.9% (35/48)], with a statistical difference (χ²=5.423; P=0.009). Before the treatment, there were no statistical differences in the radiation dermatitis grade, scores of RISRAS, NRS, and KPS, and levels of IL-6 and CRP between the two groups (all P>0.05). After the treatment, the proportion of the patients with > radiation dermatitis grade Ⅰ, scores of RISRAS and NRS, and levels of IL-6 and CRP in the study group were lower than those in the control group [20.8% (10/48) vs. 45.8% (22/48), (3.22±1.65) vs. (6.17±1.97), (0.47±0.21) vs. (1.11±0.62), (26.13±4.71) μg/L vs. (34.17±5.62) μg/L, and (7.22±1.91) mg/L vs. (10.75±2.13) mg/L]; the score of KPS in the study group was higher than that in the control group [(85.11±12.45) vs. (72.21±11.54)]; there were statistical differences (all P<0.05). No significant adverse reactions were observed in either group. Conclusion　Aloe combined with Lianchuang Shenji ointment for nasopharyngeal carcinoma patients with radiation dermatitis is an effective and safe method, providing a new option for clinical treatment.

Key words:

Nasopharyngeal carcinoma, Aloe, Lianchuang Shenji ointment, Radiation dermatitis, Clinical study