关键词:

鼻咽癌, 外泌体, 生物钟基因, 昼夜节律

Abstract:

Nasopharyngeal carcinoma is a polygenic genetic disease with racial susceptibility and high familial predisposition, which often involves the interaction between multiple genes or between genes and the environment. Exosomes derived from nasopharyngeal carcinoma are involved in the regulation of physiological and pathological activities, such as tumor immune response, angiogenesis, cell proliferation, invasion, migration, and resistance to radiotherapy and chemotherapy, are potential carriers for the formation and development of nasopharyngeal carcinoma, and play a key role in regulating the tumor and host microenvironment. In addition, the development of cancer is also related to the disruption of circadian rhythms, and biological clock genes are involved in tumor proliferation, migration, invasion, metastasis, cell cycle distribution, apoptosis, detection and repair of DNA damage, and cell sensitivity to anticancer drugs or radiation. Both circadian clock genes and nasopharyngeal carcinoma exosomes have many effects on the occurrence and development of nasopharyngeal carcinoma, and whether the cell-to-cell communication and nucleic acid and protein distribution involved in nasopharyngeal carcinoma exosomes are regulated by circadian clock patterns has not yet been described. The mechanism of whether nasopharyngeal carcinoma cell-derived exosomes regulate the occurrence, development, and drug resistance of circadian genes needs to be further studied.

Key words:

Nasopharyngeal carcinoma, Exosomes, Circadian clock genes, Circadian rhythm