关键词:

肾细胞癌, 肾部分切除术, 营养支持, 免疫功能, 炎症因子

Abstract:

Objective　To explore the effects of different nutritional support methods for patients with translocated renal cell carcinoma undergoing partial nephrectomy. Methods　This prospective study included 74 patients with ectopic renal cell carcinoma who underwent partial nephrectomy at Department of Urology, Shangluo Central Hospital from February 2021 to April 2023. The patients were divided a parenteral nutrition group (37 cases) and an enteral nutrition group (37 cases) by computer coding. There were 11 males and 26 females in the parenteral nutrition group; they were (45.83±4.67) years old. There were 13 males and 24 females in the enteral nutrition group; they (45.57±4.33) years old. The parenteral nutrition group took parenteral nutritional support on the basis of standard care. The enteral nutrition group took enteral nutritional support. The nutritional parameters [hemoglobin (Hb), albumin (Alb), transferrin (TRF), and prealbumin (PA)], immune markers (CD3⁺, CD4⁺, and CD8⁺), and inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-8] before and after the intervention and incidences of adverse reactions during the intervention were compared between the two groups by t and χ² tests. Results　Before the intervention, there were no statistical differences in the levels of Hb, Alb, TRF, PA, CD3⁺, CD4⁺, CD8⁺, TNF-α, IL-6, and IL-8 between the two groups (all P>0.05). After the intervention, the levels of Hb, Alb, TRF, PA, CD3⁺, and CD4⁺ in the enteral nutrition group were higher than those in the parenteral nutrition group [(126.73±11.26) g/L vs. (117.89±11.03) g/L, (37.41±5.88) g/L vs. (32.76±5.92) g/L, (2.98±0.44) g/L vs. (2.67±0.46) g/L, (239.73±23.70) mg/L vs. (217.46±22.54) mg/L, (51.30±5.86)% vs. (42.58±5.07)%, and (42.67±3.46)% vs. (37.34±3.41)]; the levels of CD8⁺, TNF-α, IL-6, and IL-8 in the enteral nutrition group were lower than those in the parenteral nutrition group [(27.57±3.19)% vs. (33.46±3.27)%, (18.46±2.57) ng/L vs. (22.34±2.73) ng/L, (43.26±4.35) ng/L vs. (54.67±4.97) ng/L, and (37.92±4.08) mg/L vs. (42.26±4.31) mg/L]; there were statistical differences (t=3.411, 3.390, 2.962, 4.142, 6.845, 6.674, 7.842, 6.295, 10.508, and 4.448; all P<0.05). There was no statistical difference in the incidence of adverse reactions between the two groups during the intervention (χ²=0.725; P=0.394). Conclusion　Enteral nutritional support can improve the nutritional status, immune function, and inflammatory levels in patients with ectopic renal cell carcinoma after partial nephrectomy.

Key words:

Renal cell carcinoma, Partial nephrectomy, Nutritional support, Immune function, Inflammatory cytokines