削除术联合湿润烧伤膏治疗脂溢性角化病患者疗效观察

doi:10.3760/cma.j.issn.1007-1245.2023.20.019

国际医药卫生导报 ›› 2023, Vol. 29 ›› Issue (20): 2914-2918.DOI: 10.3760/cma.j.issn.1007-1245.2023.20.019

削除术联合湿润烧伤膏治疗脂溢性角化病患者疗效观察

刘柳宏¹ 吴树毅² 郑秀芬³ 许教雄⁴ 章恋¹ 傅铮铮¹ 郑雯¹ 何仁亮¹

¹南方医科大学皮肤病医院皮肤外科与皮肤肿瘤科，广州　510091；²中山市中医院皮肤科，中山　528400；³南方医科大学顺德医院皮肤科，佛山　528418；⁴中山市黄圃人民医院皮肤科，中山　528429

收稿日期:2023-05-27 出版日期:2023-10-15 发布日期:2023-11-06
通讯作者: 何仁亮，Email：1304974336@qq.com
基金资助:
中国红十字基金会徐荣祥再生生命公益基金科研项目（2021GY01）

Resection and moist exposed burn ointment for patients with seborrheic keratosis

Liu Liuhong¹, Wu Shuyi², Zheng Xiufen³, Xu Jiaoxiong⁴, Zhang Lian¹, Fu Zhengzheng¹, Zheng Wen¹, He Renliang¹

¹Department of Dermatologic Surgery and Tumors, Dermatology Hospital of Southern Medical University, Guangzhou 510091, China; ²Department of Dermatology, Zhongshan Traditional Chinese Medicine Hospital, Zhongshan 528400, China; ³Department of Dermatology, Shunde Hospital of Southern Medical University, Foshan 528418, China; ⁴Department of Dermatology, Huangpu People's Hospital, Zhongshan 528429, China

Received:2023-05-27 Online:2023-10-15 Published:2023-11-06
Contact: He Renliang, Email: 1304974336@qq.com
Supported by:
Scientific Research Project of Xu Rongxiang Regenerated Life Public Welfare Fund of China Red Cross Foundation (2021GY01)

摘要/Abstract

摘要：

目的　评价削除术联合美宝湿润烧伤膏治疗初诊脂溢性角化病患者的临床疗效和不良反应。方法　本文为回顾性分析，选取2018年1月至2022年3月来自南方医科大学皮肤病医院皮肤外科、中山市中医院皮肤科、南方医科大学顺德医院皮肤科、中山市黄圃人民医院皮肤科的30例初诊为脂溢性角化病患者，共43处皮损；其中男性16例，女性14例，年龄（54.27±11.44）岁。均采用削除术联合美宝湿润烧伤膏治疗，统计创面愈合率及不良反应发生率。结果　43处皮损经组织病理检查诊断为脂溢性角化病的皮损有40处，日光性角化病的皮损有2处，病毒疣的皮损有1处。纳入本研究进行观察的40处脂溢性角化病皮损的创面平均愈合时间为（9.10±0.80） d，1处创面愈合后出现红斑，1例糖尿病患者1处创面发生了感染，经抗感染及换药处理后创面愈合，遗留有轻度瘢痕；2处创面愈合后有色素沉着，不良反应发生率为10%（2/40）。术后3个月随访中，40处创面的痊愈率为100％，随访期间，均未见皮损复发。结论　削除术联合美宝湿润烧伤膏治疗脂溢性角化病患者具有病理活检率高、临床疗效好、创面愈合时间短、不良反应少等优点。

关键词:

脂溢性角化病, 削除术, 美宝湿润烧伤膏, 创面愈合

Abstract:

Objective　To evaluate the clinical efficacy and adverse reactions of resection combined with moist exposed burn ointment (MEBO) in the treatment of patients with seborrheic keratosis. Methods　In this retrospective analysis, 43 lesions of 30 newly diagnosed patients with seborrheic keratosis were selected from departments of dermatology of Dermatology Hospital of Southern Medical University, Zhongshan Traditional Chinese Medicine Hospital, Shunde Hospital of Southern Medical University, Huangpu People's Hospital from January 2018 to March 2022. There were 16 males and 14 females; they were (54.27±11.4) years old. All the patients took resection and moist exposed burn ointment. The wound healing rate and the incidence of adverse reactions were analyzed. Results　A mong the 43 lesions confirmed as seborrheic keratosis, 40 had skin lesion, 2 were diagnosed as actinic keratosis, and 1 was diagnosed as viral warts by the pathological examination. Forty seborrheic keratosis lesions were included in this study for observation. The wound healing time was (9.10±0.80) days; erythema occurred in 1 wound after wound healing; one diabetic patient had 1 wound infection, and the wound healed with mild scar after anti-infection and dressing change; 2 wounds had pigmentation after wound healing; the incidence of adverse reactions was 10% (2/40). After 3 months' follow-up, the recovery rate of the 40 wounds was 100%, and no recurrence of skin lesions was observed. Conclusion　Treating seborrheic keratosis by resection combined with MEBO has the advantages of a high implementation rate of pathological examination, good clinical efficacy, short wound healing time, and few adverse reactions.

Key words:

Seborrheic keratosis, Resection, Moist exposed burn ointment, Wound healing

刘柳宏吴树毅郑秀芬许教雄章恋傅铮铮郑雯何仁亮.

削除术联合湿润烧伤膏治疗脂溢性角化病患者疗效观察 [J]. 国际医药卫生导报, 2023, 29(20): 2914-2918.

Liu Liuhong, Wu Shuyi, Zheng Xiufen, Xu Jiaoxiong, Zhang Lian, Fu Zhengzheng, Zheng Wen, He Renliang.

Resection and moist exposed burn ointment for patients with seborrheic keratosis [J]. International Medicine and Health Guidance News, 2023, 29(20): 2914-2918.

参考文献

[1] 李杨,王宇令,余江,等. 真皮浅层切除术及病理活检在脂溢性角化病诊治中的应用[J]. 中国美容整形外科杂志,2018,29(3):161-164. DOI:10.3969/j.issn.1673-7040. 2018.03.011.
[2] Sun MD, Halpern AC. Advances in the etiology, detection, and clinical management of seborrheic keratoses[J]. Dermatology, 2022,238(2):205-217. DOI: 10.1159/000517070.
[3] Karadag AS, Parish LC. The status of the seborrheic keratosis[J]. Clin Dermatol, 2018 ,36(2):275-277. DOI: 10.1016/j.clindermatol.2017.09.011.
[4] 李卫,吴晓峰,黎明. 瘢痕削除后刃厚皮片移植治疗烧伤后增生性瘢痕[J]. 中国临床医学,2006,13(4):688-689. DOI:10.3969/j.issn.1008-6358.2006.04.073.
[5] 何仁亮,黄桃源. 湿润烧伤膏在皮肤科的临床应用[J]. 中国烧伤创疡杂志,2015(4):294-299. DOI:10.3969/j.issn. 1001-0726.2015.04.012.
[6] 陈福祥,王海伦. 脂溢性角化病并发日光性角化病及基底细胞癌1例[J]. 中国皮肤性病学杂志,2018,32(6):682-684. DOI:10.13735/j.cjdv.1001-7089.201705063.
[7] 李晓辉,翁智胜,彭洁雯,等. 脂溢性角化病108例临床、病理及误诊分析[J]. 临床误诊误治,2020,33(8):27-30. DOI:10.3969/j.issn.1002-3429.2020.08.007.
[8] 胡友红,张爱华,易庆阳,等.0.1%他扎罗汀联合0.005%卡泊三醇软膏治疗脂溢性角化病疗效观察与分析[J].中国美容医学,2016,25(3):52-53.DOI:10.15909/j.cnki.cn61-1347/r.001059.
[9] 董郁红,赵小玲.Q开关532 nm激光联合超脉冲CO2激光治疗脂溢性角化病疗效观察[J].中国美容医学,2021,30(10):105-108.DOI:10.15909/j.cnki.cn61-1347/r.004691.
[10] 朱明明,刘科峰.Q开关755nm翠绿宝石激光与CO2点阵激光治疗脂溢性角化病疗效对比[J].中国美容医学,2019,28(3):80-82.DOI:10.15909/j.cnki.cn61-1347/r.002922.
[11] 钟华. Q 开关倍频Nd : YAG 激光联合电离子治疗脂溢性角化病的疗效观察[J]. 微创医学, 2019,14(1):30,98-99.
[12] 姚晓东,崔晓美,许攀,等. 超脉冲二氧化碳点阵激光治疗脂溢性角化107例疗效观察[J]. 中国医疗美容,2018,8(10):53-56. DOI:10.19593/j.issn.2095-0721.2018.10.014.
[13] 罗东平,徐淑萍,盛虹. 紫翠宝石激光与电离子治疗脂溢性角化病的疗效观察[J]. 皮肤病与性病,2020,42(5):720-722. DOI:10.3969/j.issn.1002-1310.2020.05.047.
[14] 周密,高慧. 脂溢性角化的治疗进展[J]. 中国医疗美容,2020,10(9):143-148. DOI:10.19593/j.issn.2095-0721. 2020.09.036.
[15] Baumann LS, Blauvelt A, Draelos ZD, et al. Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302)[J]. J Am Acad Dermatol, 2018 ,79(5):869-877. DOI: 10.1016/j.jaad.2018.05.044.
[16] 唐强,唐乾利. 磺胺嘧啶银与美宝湿润烧伤膏治疗四肢Ⅱ度烧伤的疗效比较[J]. 广西医学,2019,41(4):405-408. DOI:10.11675/j.issn.0253-4304.2019.04.04.
[17] El-Hadidy MR, El-Hadidy AR, Bhaa A, et al. Role of epidermal stem cells in repair of partial-thickness burn injury after using Moist Exposed Burn Ointment (MEBO(®)) histological and immunohistochemical study[J]. Tissue Cell, 2014 ,46(2):144-151. DOI: 10.1016/j.tice.2014.01.002.
[18] Fu HD, Wang S, Ge B, et al. Nerve growth factor and substance P may be involved in moist exposed burn ointment-mediated chronic refractory wound healing[J]. Exp Ther Med, 2018 ,16(3):1987-1993. DOI: 10.3892/etm.2018.6390.
[19] 唐乾利,李利青,李辉,等. MEBT/MEBO对大鼠糖尿病足创面组织TGF-β1、Smad3、P-smad3表达及形态学结构的影响[J]. 重庆医科大学学报,2017,42(3):283-288. DOI:10.13406/j.cnki.cyxb.001179.
[20] 王洪生. 皮肤原位再生医疗技术治疗糖尿病足溃疡的临床诊治规范[J]. 中国烧伤创疡杂志,2016,28(3):155-191. DOI:10.3969/j.issn.1001-0726.2016.03.001.
[21] Zheng A, Ma H, Liu X, et al. Effects of moist exposed burn therapy and ointment (MEBT/MEBO) on the autophagy mTOR signalling pathway in diabetic ulcer wounds[J]. Pharm Biol, 2020 ,58(1):124-130. DOI: 10.1080/13880209.2019.1711430.

削除术联合湿润烧伤膏治疗脂溢性角化病患者疗效观察

Resection and moist exposed burn ointment for patients with seborrheic keratosis

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 3

编辑推荐

Metrics

[1]	王慧孙亚峰陈明环王倩刘平. 生肌止痛方熏洗结合抗菌药物治疗肛周脓肿患者的临床效果 [J]. 国际医药卫生导报, 2023, 29(16): 2281-2285.
[2]	张盈, 崔光怀, 刘飞飞, 黄幸子, 代淑敏, 李琼羽, 裴梦鸽, 刘文明. 美宝湿润烧伤膏在创面修复中的应用研究进展 [J]. 国际医药卫生导报, 2022, 28(8): 1134-1137.
[3]	娄秀娥, 杨焕芝, 李静. 封闭负压引流技术联合针对性护理对糖尿病足溃疡区血管新生的影响[J]. 国际医药卫生导报, 2021, 27(6): 920-924.