关键词:

肛周脓肿, 生肌止痛方, 中药熏洗, 抗菌治疗, 创面愈合

Abstract:

Objective　To observe the effect of fumigation and washing with Shengji Zhitong Fang combined with antibacterial drugs for patients with perianal abscess. Methods　One hundred and twenty-three patients with perianal abscess treated at Shangqiu First People's Hospital from October 2020 to February 2023 were selected for the randomized controlled trial. They were divided into a control group (60 cases) and a combined group (63 cases) by the computer randomization method. There were 35 males and 25 females in the control group; they were (50.25±5.31) years old. There were 37 males and 26 females in the combined group; they were (50.33±5.25) years old. The control group received regular antimicrobial treatment. The combined group took fumigation and washing with Shengji Zhitong Fang combined with antibacterial drugs. The wound healing, improvement of inflammatory factors and pain indicators, and recovery of anal function were compared between the two groups. t test was applied. Results　Before the treatment, there were no statistical differences in epidermal growth factor (EGF), inflammatory factors, pain mediators, and anal function indicators between the two groups (all P>0.05). After the treatment, the wound healing time and scab shedding time in the combined group were shorter than those in the control group [(20.45±5.17) d vs. (23.75 ± 5.31) d and (4.33±1.25) d vs. (5.26±1.49) d], and the EGF level in the combined group was higher than that in the control group [(0.75±0.12) μg/L vs. (0.58±0.11) μg/L], with statistical differences (t=3.492, 3.757, and 8.178; all P<0.05). After the treatment, the levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin 1β (IL-1β) in the combined group were lower than those in the control group [(7.44±2.31) mg/L vs. (10.33±3.82) mg/L, (20.33±5.41) ng/L vs. (23.72±5.18) ng/L, and (60.45±10.27) ng/L vs. (67.44±10.25) ng/L], with statistical differences (t=5.105, 3.546, and 3.777; all P<0.05). After the treatment, the levels of 5-hydroxytryptamine (5-HT) and serum P substance (SP) and the score of Visual Analogue Scale (VAS) in the combined group were lower than those in the control group [(0.31±0.12) μmol/L vs. (0.55±0.23) μmol/L, (8.45±2.33) ng/L vs. (10.76±3.25) ng/L, and (3.13±0.26) vs. (4.77±1.27)], with statistical differences (t=7.305, 4.547, and 10.033; all P<0.05). The Wexner scores 3, 7, 14 d after the treatment in the combined group were lower than those in the control group [(10.35±2.27) vs. (12.25±3.49), (7.66±2.13) vs. (10.28±3.16), and (5.04±1.32) vs. (7.79±2.45)], with statistical differences (t=3.596, 5.415, and 7.800; all P<0.05). Conclusion　Fumigation and washing with Shengji Zhitong Fang combined with antibacterial drugs for patients with perianal abscess can promote their wound healing and anal function, and alleviate their inflammation and pain.

Key words:

Perianal abscess, Shengji Zhitong Fang, Fumigation and washing with traditional Chinese medicine, Antibacterial therapy, Wound healing