关键词: 同型半胱氨酸, 前庭性偏头痛, 血脂, 临床研究

Abstract: Objective　To analyze the changes of homocysteine (Hcy) and blood lipids in patients with vestibular migraine (VM), and to provide references for the clinical diagnosis and treatment of VM. Methods　This was a prospective clinical trial study. From December 2022 to December 2024,72 patients with VM treated in Lianyungang Hospital of TCM were selected as an experimental group, including 18 males and 54 females, aged (55.47±9.23) years. At the same time, 40 healthy subjects were selected as a control group, including 12 males and 28 females, aged (58.38±8.98) years. The patients in the experimental group with VM were divided into a young group (age<50 years), a middle-aged group (50 years≤age<60 years), and a elderly group (age≥60 years). The lipid profiles [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)] and homocysteine (Hcy) levels of the two groups were compared, and a one-way analysis of variance was performed on the lipid profiles and Hcy levels of the patients in the experimental group. The statistical methods were t test and F test. Results　The levels of TC, TG, LDL-C, and Hcy in the experimental group were all higher than those in the control group [(4.85±0.78) mmol/L vs. (4.37±0.88) mmol/L, (2.13±0.57) mmol/L vs. (1.62±0.45) mmol/L,(2.89±0.67) mmol/L vs. (2.43±0.72) mmol/L, and (14.47±3.95) μmol/L vs. (11.37±3.20) μmol], with statistical differences (all P<0.05). The levels of TC, TG, HDL-C, LDL-C, and Hcy in the youth group were (3.97±0.74) mmol/L, (1.71±0.31) mmol/L, (1.52±0.39) mmol/L, (2.13±0.58) mmol/L, and (11.67±2.59) μmol/L, the levels in the middle-aged group  (4.79±0.77) mmol/L, (2.39±0.59) mmol/L, (1.43±0.32) mmol/L, (2.69±0.56) mmol/L, and (14.25±3.29) μmol/L, and the levels in the elderly group (5.46±0.52) mmol/L, (2.43±0.55) mmol/L, (1.15±0.12) mmol/L, (3.76±0.57) mmol/L, and (17.93±3.67) μmol/L. There were no significant differences in TG between the middle-aged group and the elderly group and in HDL-C and Hcy between the young group and the middle-aged group (all P>0.05). There were significant differences in the other indexes between the two groups (all P<0.05). Conclusions　The metabolic disorders of lipids and higher Hcy in patients with VM may be risk factors for VM. Early discovery and intervention of the metabolic disorders of lipids and higher Hcy are beneficial to the clinical diagnosis and treatment of VM patients.

Key words:

Homocysteine, Vestibular migraine, Blood lipids, Clinical study