阿片类药物对围手术期睡眠的影响研究进展

doi:10.3760/cma.j.cn441417-20241230-19011

国际医药卫生导报 ›› 2025, Vol. 31 ›› Issue (19): 3223-3227.DOI: 10.3760/cma.j.cn441417-20241230-19011

阿片类药物对围手术期睡眠的影响研究进展

周业建¹ 王安琪¹ 关英超¹ 都淑萍¹ 法志强²

¹威海市立医院麻醉科，威海 264200；²南方医科大学珠江医院神经外科，广州 510282

收稿日期:2024-12-30 出版日期:2025-10-01 发布日期:2025-10-24
通讯作者: 法志强，Email：fzqqz@163.com
基金资助:
恩泽疼痛管理医学研究项目（ezmr2024-011）

Research progress on the effects of opioid drugs on sleep during the perioperative period

Zhou Yejian¹, Wang Anqi¹, Guan Yingchao¹, Du Shuping¹, Fa Zhiqiang²

¹Department of Anesthesiology, Weihai Municipal Hospital, Weihai 264200, China; ²Department of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China

Received:2024-12-30 Online:2025-10-01 Published:2025-10-24
Contact: Fa Zhiqiang, Email: fzqqz@163.com
Supported by:
Enze Pain Management Medical Research Project (ezmr2024-011)

摘要/Abstract

摘要：

阿片类药物作为围手术期常用镇痛药，作用于中枢神经系统，通过模拟内源性阿片肽的作用，有效地缓解了手术带来的痛苦，在减轻患者疼痛、提高舒适度及促进快速恢复方面发挥关键作用。然而阿片类药物可能干扰睡眠结构，导致睡眠质量下降，这不仅降低患者生活质量，还可能延缓康复进程、增高术后并发症风险。本文梳理阿片类药物对围手术期睡眠的影响及其作用机制，为临床合理使用阿片类药物提供参考，并探讨相应的防治措施，帮助医务人员在确保有效镇痛的同时，减轻对围手术期睡眠质量的负面影响，从而提高患者的康复效果和生活质量。

关键词:

阿片类药物, 睡眠障碍, 围手术期, 麻醉, 进展

Abstract:

Opioid drugs, as commonly used analgesics during the perioperative period, act on the central nervous system. By mimicking the effects of endogenous opioid peptides, they effectively alleviate the pain caused by surgery, playing a crucial role in reducing patients' pain, enhancing their comfort, and facilitating a rapid recovery. However, opioid drugs may disrupt the sleep structure, resulting in a decline in sleep quality. This not only reduces the quality of life of patients but also may delay the recovery process and increase the risk of postoperative complications. This article reviews the effects of opioid drugs on perioperative sleep and the underlying mechanisms, providing a reference for the rational use of opioid drugs in clinical practice. It also explores corresponding prevention and treatment measures, helping medical staff ensure effective pain relief while reducing the negative impact on the sleep quality during the perioperative period, thereby improving the rehabilitation effect and quality of life of patients.

Key words:

Opioid drugs, Sleep disorders, Perioperative period, Anesthesia, Progress

周业建王安琪关英超都淑萍法志强.

阿片类药物对围手术期睡眠的影响研究进展 [J]. 国际医药卫生导报, 2025, 31(19): 3223-3227.

Zhou Yejian, Wang Anqi, Guan Yingchao, Du Shuping, Fa Zhiqiang.

Research progress on the effects of opioid drugs on sleep during the perioperative period [J]. International Medicine and Health Guidance News, 2025, 31(19): 3223-3227.

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阿片类药物对围手术期睡眠的影响研究进展

Research progress on the effects of opioid drugs on sleep during the perioperative period

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