Medication rules and efficacy of fumigation and washing by traditional
Chinese medicine in treatment of knee osteoarthritis

doi:10.3760/cma.j.issn.1007-1245.2022.19.002

Abstract

Abstract: Objective　To explore the rules treating knee osteoarthritis with herbal fumigation based on the traditional Chinese medicine heritage support platform. Methods　The clinical research literatures on the treatment of knee osteoarthritis with Chinese herbal fumigation included in the full-text databases, CNKI, Wanfang, VIP, and CBMdisc, from 1990 to 2020 were analyzed, and the data were mined and analyzed for drug frequencies, combinations, allotropes, and new formula combinations using the TCM Heritage Assist System. Results　A total of 1 449 literatures were searched, and 204 prescriptions and 166 types of Chinese medicines were included, with a use frequency of 2 552 times. The top three drugs were safflower, Phryma leptostachya subsp. asiatica (Hara) Kitamura, and Lycopodium jaPonicum Thunb. The wind-dampness-dispelling and blood-stasis-invigorating drug was commonly used. The main meridians were the Liver, Kidney, and Spleen. The association rules for Chinese herbal medicines were analyzed and ranked in terms of confidence, with "Myrrh → Boswellia" being the highest for the two-association and "Boswellia + Xanthium → Myrrh" being the highest for the three-association. Conclusions　Fumigation and washing by traditional Chinese medicine in the treatment of knee osteoarthritis has reliable clinical efficacy. The main rules of medication are dispelling wind and dampness, promoting blood circulation and removing stasis, Buyi, clearing heat, and relieving symptoms. Dampness-dispelling drugs can be combined with drugs promoting blood circulation and removing blood stasis, tonifying drugs, heat-clearing drugs, and symptom-relieving drugs, and dampness-dispelling drugs play a major role in the treatment.

Key words: Knee osteoarthritis, Traditional Chinese medicine heritage support platform, Data mining, Herbal fumigation, Medication rules

摘要： 目的　运用中医传承辅助平台分析中药熏洗治疗膝关节骨性关节炎的用药规律。方法　分析收录在中国期刊全文数据库知网、万方、维普、生物医学1990—2020年的中药熏洗治疗膝关节骨性关节炎的临床研究文献，运用中医传承辅助系统对数据进行药物频数、组合、配伍、新方组合等的挖掘分析。结果　检索文献1 449条，纳入处方204首，中药166种，使用频次2 552次，排前三的药物为红花、透骨草、伸筋草，常用药类为祛风湿、活血化瘀药；主要归经为肝、肾、脾经。对中药进行关联规则分析，二联关联以“没药→乳香”最高，三联关联以“乳香+伸筋草→没药”最高。结论　中药熏洗治疗膝关节骨性关节炎临床疗效可靠，用药规律以祛风湿为主，兼以活血化瘀、补益、清热、解表；祛风湿药可与活血化瘀药、补益药、清热药、解表药联合应用，并且祛风湿药在治疗中起主要作用。

关键词: 膝关节骨性关节炎, 中医传承辅助平台, 数据挖掘, 中药熏洗, 用药规律

Gong Xiuying. Medication rules and efficacy of fumigation and washing by traditional Chinese medicine in treatment of knee osteoarthritis[J]. International Medicine and Health Guidance News, 2022, 28(19): 2671-2676.

龚秀英. 基于中医传承辅助平台的中药熏洗治疗膝关节骨性关节炎的用药规律[J]. 国际医药卫生导报, 2022, 28(19): 2671-2676.

References

[1] 王佩,张兴平,高云,等.基于临床科研共享系统建立膝骨关节炎分级模型[J].中国骨伤,2018,31(6):528-533.DOI:10.3969/j.issn.1003-0034.2018.06.009.
[2] 王一全,高明利.膝骨关节炎中西医诊治研究进展[J].实用中医内科杂志,2021,35(3):8-12.DOI:10.13729/j.issn. 1671-7813.Z20200741.
[3] 张旭斌,华臻,王建伟.中医外治法治疗膝骨关节炎的最新研究进展[J].针灸临床杂志,2018,34(11):79-82.DOI:10.3969/j.issn.1005-0779.2018.11.023.
[4] 张师侥,关雪峰.中医外治法治疗膝骨性关节炎最新进展[J].中国骨质疏松杂志,2016,22(7):907-911.DOI:10.3969/j.issn.1006-7108.2016.07.024.
[5] 李宁,李鼎鹏,谢兴文,等.中医外治法为主治疗膝关节滑膜炎研究概况[J].中国骨质疏松杂志,2017,23(9):1224-1231.DOI:10.3969/j.issn.1006-7108.2017.09.023.
[6] 姜华,辛仲斌.中医药治疗足跟痛的临床研究进展[J].中国中医骨伤科杂志,2011,19(5):71-73.
[7] 王骥.中医药疗法治疗膝关节骨性关节炎研究进展[J].中国临床医生,2015,(3):36-39.DOI:10.3969/j.issn.1008- 1089. 2015.03.012.
[8] 高学敏.中药学[M].2版.北京:中国中医药出版社,2007:21-611.
[9] 国家药典委员会.中华人民共和国药典[S].一部.北京:中国医院科技出版社,2015:3-384.
[10] 徐卫华,赵彦,王鸿,等.等速训练对早中期髌骨软骨病的康复疗效研究[J].中国康复,2016,31(5):365-367.DOI:10.3870/zgkf.2016.05.013.
[11] 马影蕊,张玉倩.中医对膝关节骨性关节炎的认识与研究[J].中医临床研究,2019,11(25):146-148.
[12] 赵慧敏,高明利.从"肝肾同源"论治类风湿关节炎[J].云南中医中药杂志,2019,40(12):28-30.DOI:10.3969/j.issn.1007- 2349.2019.12.008.
[13] 蔡国锋,蔡国梁,庄哲,等.毫火针联合运动疗法治疗早期膝关节骨性关节炎的疗效及对血清NO的影响[J].针灸临床杂志,2020,36(7):20-25.DOI:10.3969/j.issn.1005-0779. 2020.07.007.
[14] 黄韶辉,李瑞星.温针灸联合中药熏洗治疗膝关节骨性关节炎临床研究[J].新中医,2020,52(7):126-128.DOI:10.13457/j.cnki.jncm.2020.07.038.
[15] Zhang L, Wang Y, Yang Y, et al. High Tumor penetration of paclitaxel loaded ph sensitive cleavable liposomes by depletion of tumor collagen i in breast cancer[J]. ACS Appl Mater Interfaces, 2015,7(18):9691-9701. DOI: 10.1021/acsami.5b01473.
[16] 陈建文.中药熏洗配合功能锻炼治疗膝骨性关节炎的临床研究[J].中国医药科学,2017,7(8):231-233.DOI:10.3969/j.issn.2095-0616.2017.08.073.
[17] 周斌,王珍珍,陈浩雄.平衡训练结合中药熏洗治疗膝骨性关节炎疗效观察[J].现代中西医结合杂志,2019,28(33):3685-3688.DOI:10.3969/j.issn.1008-8849.2019.33.009.
[18] 吴正远.中医辨证结合功能锻炼治疗膝骨性关节炎临床观察[J].四川中医,2015,33(12):153-154.
[19] 黄明辉.中药熏洗联合西药治疗对膝关节骨性关节炎患者疼痛及膝关节功能的影响[J].临床医学工程,2020,27(5):583-584.DOI:10.3969/j.issn.1674-4659.2020.05.0583.
[20] 李勇.通络活血方熏洗对骨折后关节僵硬患者关节活动度及日常生活能力的影响[J].健康之友,2019,(22):93-94.
[21] 李宝军,刘志强.红花药理分析及临床应用研究[J].亚太传统医药,2014,10(15):44-45.
[22] 贾佼佼,苗明三.红花的现代药理与新用[J].中医学报,2013,28(11):1682-1685.DOI:10.16368/j.issn.1674-8999. 2013.11.059.
[23] 张永峰,曾常茜,黄雯,等.透骨草化学成分和药理学作用研究进展[J].中华中医药学刊,2010,28(9):1960-1962. DOI:10.13193/j.archtcm.2010.09.170.zhangyf.054.
[24] 刘静,年华,徐熠,等.伸筋草生物碱对佐剂性关节炎大鼠的抗炎作用及机制研究[J].药物评价研究,2019,42(5):869-872.DOI:10.7501/j.issn.1674-6376.2019.05.010.
[25] 黄竞杰,杨俊兴,陈浩雄.牛膝总皂苷治疗膝骨关节炎的药理研究进展[J].中药新药与临床药理,2021,32(4):592-595.DOI:10.19378/j.issn.1003-9783.2021.04.022.
[26] 李志红,杨孟孟,杨伟伟,等.中药熏洗对膝关节骨性关节炎患者膝关节功能、血管内皮生长因子、软骨寡聚基质蛋白水平的影响[J].陕西中医,2019,40(9):1226-1228.DOI:10.3969/j.issn.1000-7369.2019.09.021.
[27] 李岳泽.基于铁调素探讨左归丸对去卵巢大鼠骨质疏松症的治疗作用及机理[D].北京:中国中医科学院,2016.
[28] 黄文豪,陈博威,陈宇奇,等.刍议肝主筋与太阳主筋[J].中国针灸,2020,40(9):989-990.DOI:10.13703/j.0255-2930. 20190802-0004.
[29] 陈善文,温志立,林星镇.浅谈"脾主肌肉"在相关疾病中的作用[J].江西中医药大学学报,2021,33(1):7-9.
[30] 翁炎佳.独活寄生汤配合芬必得乳膏外用治疗膝关节骨性关节炎82例疗效观察[J].中国现代药物应用,2012,06(14):15-16.DOI:10.3969/j.issn.1673-9523.2012.14.009.
[31] 吴昊.独活寄生汤对全膝关节置换术后镇痛与促进康复效果的评价[D].唐山:华北理工大学,2019.
[32] 杨捷.影响四物汤及其类方功效的诸因素研究[D]. 成都:成都中医药大学,2017.
[33] 唐秀松,庞宇舟,方刚,等.基于网络药理学探讨独活寄生汤治疗类风湿关节炎作用机制[J].辽宁中医药大学学报,2021,23(1):87-93.DOI:10.13194/j.issn.1673- 842x. 2021.01.021.
[34] 周子齐,关雪峰,杨永菊.独活寄生汤治疗膝骨关节炎机制的研究进展[J].中华中医药杂志,2021,36(5):2859-2862.
[35] 阿古达木,陈薇薇,徐杉,等.独活寄生汤临床运用及药理研究进展[J].辽宁中医药大学学报,2020,22(10):163-167.DOI:10.13194/j.issn.1673-842x.2020.10.039.
[36] 田照,庞宇舟,袁德培,等.小活络丹治疗类风湿关节炎的网络药理学及实验机制研究[J].时珍国医国药,2020,31(4):800-805.DOI:10.3969/j.issn.1008-0805.2020.04.009.
[37] 王家卿,张楠.中西医结合治疗浅表组织急性化脓性感染48例[J].云南中医中药杂志,2014,35(1):30.DOI:10.16254/j.cnki.53-1120/r.2014.01.013.

Medication rules and efficacy of fumigation and washing by traditional Chinese medicine in treatment of knee osteoarthritis

基于中医传承辅助平台的中药熏洗治疗膝关节骨性关节炎的用药规律

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