Medication rules of traditional Chinese medicine in treatment of Crohn's
disease based on data mining

doi:10.3760/cma.j.issn.1007-1245.2022.05.006

International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (5): 617-620.DOI: 10.3760/cma.j.issn.1007-1245.2022.05.006

• Scientific Research • Previous Articles Next Articles

Medication rules of traditional Chinese medicine in treatment of Crohn's disease based on data mining

Zeng Cheng¹, You Shaowei², Wang Wensu², He Diancheng²

¹Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China; ²The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550003, China

Received:2021-11-05 Online:2022-03-01 Published:2022-04-01
Contact: You Shaowei, Email: 1103714296@qq.com
Supported by:
Research Project of Science and Technology of Chinese Medicine and National Medicine of Guizhou Bureau of Chinese Medicine Management (QZYY-2019-037)

基于数据挖掘探讨中药治疗克罗恩病的用药规律

曾程¹ 游绍伟² 王文素² 何典城²

¹贵州中医药大学，贵阳　550025；
²贵州中医药大学第二附属医院，贵阳　550003

通讯作者: 游绍伟，Email：1103714296@qq.com
基金资助:
贵州省中医药管理局中医药、民族医药科学技术研究课题（QZYY-2019-037）

Abstract

Abstract: Objective　To explore the medication rules of traditional Chinese medicine in the treatment of Crohn's disease, and to provide new ideas for clinical medication and related mechanism research. Methods　According to the inclusion and exclusion criteria, Crohn's disease prescriptions were collected; the network database was established; and the frequency, rate, and association rules of the data were analyzed. Results　A total of 126 prescriptions were collected, involving 166 kinds of traditional Chinese medicine; 18 kinds of which in the high frequency were atractylodis atractylodis (49.2%), Poria cohoe (42.9%), paeoniae alba (33.3%)), Angelica (27.8%), etc., which were mainly for invigorating spleen, promoting dampness, regulating qi, and promoting blood circulation. The four qi mainly were warm (46.0%), cold (24.0%), and flat (23.0%). The five tastes mainly were sweet (33.0%), bitter (30.0%), and acrid (25.0%). The meridian with the highest frequency (790) was spleen. Conclusions　In the treatment of Crohn's disease, the main drugs are invigorating spleen and dampness, regulating qi, and promoting blood circulation. The main meridians are spleen, stomach, and lung. The main drugs are Poria cohoe, atractylodis atractylodis, paeoniae alba, and tangerine bark. The drug compatibility reflects the treatment ideas from the signs and mechanism of spleen, lung, and large intestine, with addition of sedation and mood modulation drugs.

Key words: Crohn's disease, Chinese medicine, Medication rules, Data mining

摘要： 目的　探讨中医药治疗克罗恩病的用药规律，为临床用药及相关机制研究提供新的思路。方法　按照纳入和排除标准，收集2009—2020年治疗克罗恩病方剂，并建立网络数据库，对数据进行频次、频率、关联规则分析。结果　此次共收集方剂126首，涉及中药共166种，高频中药为白术（49.2%）、茯苓（42.9%）、白芍（33.3%）、当归（27.8%）等18种，以健脾利湿、理气活血为主，四气以温（46.0%）、寒（24.0%）、平（23.0%）为主，五味以甘（33.0%）、苦（30.0%）、辛（25.0%）为主，归经以脾经（频率为790）为最。结论　治疗克罗恩病大多以健脾利湿、理气活血为主，重要归经是脾、胃、肺，核心药对是茯苓、白术、白芍、陈皮。药物配伍上体现了从脾论治、肺与大肠相表里等治疗思想，同时加入镇静、调情志的药物。

关键词: 克罗恩病, 中药, 用药规律, 数据挖掘

Zeng Cheng, You Shaowei, Wang Wensu, He Diancheng. Medication rules of traditional Chinese medicine in treatment of Crohn's disease based on data mining[J]. International Medicine and Health Guidance News, 2022, 28(5): 617-620.

曾程, 游绍伟, 王文素, 何典城. 基于数据挖掘探讨中药治疗克罗恩病的用药规律[J]. 国际医药卫生导报, 2022, 28(5): 617-620.

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Medication rules of traditional Chinese medicine in treatment of Crohn's disease based on data mining

基于数据挖掘探讨中药治疗克罗恩病的用药规律

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