Abstract:

Objective　To observe the therapeutic effect of Bushen Huoxue Formula combined with western medicine in the treatment of patients with ovulation disorder infertility of Shenxu Xueyu type. Methods　Eighty patients with ovulation disorder infertility of Shenxu Xueyu type treated at Yan'an Hospital of Traditional Chinese Medicine from January 2020 to May 2023 were selected for the randomized controlled trial, and were divided into an experimental group and a control group, with 40 cases in each group. The patients in the control group were (26.87±9.55) years old; their disease course was (1.95±0.63) years; their body mass index was (24.87±3.58) kg/m²; their basic body temperature was (36.12±1.32) ℃; their menstruation volume was (17.12±2.67) ml. The patients in the experimental group were (27.62±8.79) years old; their disease course was (2.04±0.50) years; their body mass index was (25.62±2.59) kg/m²; their basic body temperature was (36.25±0.97) ℃; their menstruation volume was (16.27±3.85) ml. The control group took clomiphene citrate, while the experimental group took clomiphene citrate and Bushen Huoxue Formula. Each treatment course lasted 5 days; both groups were treated 8 courses. The endometrial thicknesses, follicle counts, maximum follicle diameters, and serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E₂) before and after the treatment, treatment efficacies, and adverse reactions in both groups were recorded. t and χ² tests were used for the statistical analysis. Results　After the treatment, the endometrial thickness, follicle count, maximum follicle diameter, and serum levels of FSH, LH, and E₂ in the experimental group were higher than those in the control group [(9.17±3.62) mm vs. (7.07±2.06) mm, 6.80±2.57 vs. 4.19±2.66, (16.81±3.42) mm vs. (15.29±3.19) mm, (9.91±2.56) IU/L vs. (8.82±1.69) IU/L, (10.61±2.39) IU/L vs. (7.62±3.31) IU/L, and (89.12±13.46) ng/L vs. (65.14±15.56) ng/L; t=3.189, 4.463, 2.056, 2.247, 4.623, and 7.372; all P<0.05]. The total effective rate in the experimental group was higher than that in the control group [85.00% (34/40) vs. 57.50% (23/40); χ²=6.102; P=0.014]. The overall incidence rate of adverse reactions in the experimental group was lower than that in the control group [5.00% (2/40) vs. 27.50% (11/40); χ²=5.878; P=0.015]. Conclusion　Bushen Huoxue Formula combined with western medicine in the treatment of patients with ovulation disorder infertility of Shenxu Xueyu type is effective.

Key words:

Ovulation disorder infertility, Traditional Chinese medicine, Bushen Huoxue , Formula, Clomiphene citrate

摘要：

目的　观察补肾活血方联合枸橼酸氯米芬治疗肾虚血瘀型排卵障碍性不孕患者的效果。方法　选取2020年1月至2023年5月延安市中医医院收治的肾虚血瘀型排卵障碍性不孕患者80例进行随机对照试验。采用随机数字表法将其分为试验组和对照组，各40例。对照组年龄（26.87±9.55）岁，病程（1.95±0.63）年，体重指数（24.87±3.58）kg/m²，基础体温（36.12±1.32）℃，月经量（17.12±2.67）ml。试验组年龄（27.62±8.79）岁，病程（2.04±0.50）年，体重指数（25.62±2.59）kg/m²，基础体温（36.25±0.97）℃，月经量（16.27±3.85）ml。对照组给予枸橼酸氯米芬治疗，试验组在此基础上加用补肾活血方。每个疗程5 d，两组均治疗8个疗程。记录两组治疗前后子宫内膜厚度、卵泡数、卵泡长径、血清促卵泡激素（follicle-stimulating hormone，FSH）、黄体生成素（luteinizing hormone，LH）和雌二醇（estradiol，E₂）水平、疗效及不良反应发生情况。采用t检验和χ²检验进行统计学分析。结果　治疗后，试验组子宫内膜厚度、卵泡数、卵泡长径均高于对照组［（9.17±3.62）mm比（7.07±2.06）mm、（6.80±2.57）个比（4.19±2.66）个、（16.81±3.42）mm比（15.29±3.19）mm；t=3.189、4.463、2.056，均P<0.05］。治疗后，试验组血清FSH、LH、E₂水平均高于对照组［（9.91±2.56）IU/L比（8.82±1.69）IU/L、（10.61±2.39）IU/L比（7.62±3.31）IU/L、（89.12±13.46）ng/L比（65.14±15.56）ng/L；t=2.247、4.623、7.372，均P<0.05］。试验组治疗总有效率高于对照组［85.00%（34/40）比57.50%（23/40）；χ²=6.102，P=0.014］。试验组总不良反应发生率低于对照组［5.00%（2/40）比27.50%（11/40）；χ²=5.878，P=0.015］。结论　补肾活血方联合枸橼酸氯米芬治疗肾虚血瘀型排卵障碍性不孕患者的效果较好。

关键词:

排卵障碍性不孕, 中药, 补肾活血方, 枸橼酸氯米芬