Abstract:

Nasopharyngeal carcinoma is a polygenic genetic disease with racial susceptibility and high familial predisposition, which often involves the interaction between multiple genes or between genes and the environment. Exosomes derived from nasopharyngeal carcinoma are involved in the regulation of physiological and pathological activities, such as tumor immune response, angiogenesis, cell proliferation, invasion, migration, and resistance to radiotherapy and chemotherapy, are potential carriers for the formation and development of nasopharyngeal carcinoma, and play a key role in regulating the tumor and host microenvironment. In addition, the development of cancer is also related to the disruption of circadian rhythms, and biological clock genes are involved in tumor proliferation, migration, invasion, metastasis, cell cycle distribution, apoptosis, detection and repair of DNA damage, and cell sensitivity to anticancer drugs or radiation. Both circadian clock genes and nasopharyngeal carcinoma exosomes have many effects on the occurrence and development of nasopharyngeal carcinoma, and whether the cell-to-cell communication and nucleic acid and protein distribution involved in nasopharyngeal carcinoma exosomes are regulated by circadian clock patterns has not yet been described. The mechanism of whether nasopharyngeal carcinoma cell-derived exosomes regulate the occurrence, development, and drug resistance of circadian genes needs to be further studied.

Key words:

Nasopharyngeal carcinoma, Exosomes, Circadian clock genes, Circadian rhythm

摘要：

鼻咽癌是一种多基因遗传病，有种族易感性及家族高发倾向，它往往涉及多个基因之间或基因与环境之间的交互作用。鼻咽癌来源的外泌体参与调控肿瘤免疫反应、血管生成、细胞增殖、侵袭、迁移和放化疗抗性等生理和病理活动，是鼻咽癌形成途径和发生发展的潜在载体，对调控肿瘤和宿主微环境起关键作用。除此之外，癌症的发展也与昼夜节律破坏有关，生物钟基因参与肿瘤增殖、迁移、侵袭、转移、细胞周期分布、凋亡、DNA损伤的检查与修复、细胞对抗癌药物或辐射的敏感性等。生物钟基因和鼻咽癌外泌体对鼻咽癌的发生发展产生多方面影响。鼻咽癌外泌体所参与的细胞间通讯、核酸及蛋白等分布是否以生物钟模式进行调节目前尚未得到描述。关于鼻咽癌细胞来源的外泌体是否通过调节昼夜节律基因对肿瘤的发生发展及耐药性的机制还有待进一步研究。

关键词:

鼻咽癌, 外泌体, 生物钟基因, 昼夜节律