Leukocyte-associated immunoglobulin-like receptor 1 in diabetes

doi:10.3760/cma.j.issn.1007-1245.2023.24.004

Abstract

Abstract:

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an immune inhibitory receptor that mediates immune suppression. It can affect the occurrence and development of various metabolic and immune diseases by regulating inflammatory responses. Type 2 diabetes mellitus is the most common form of disease that leads to insulin production defects. It is now recognized that the inflammatory response is a result of immune response to high blood glucose levels. This low-grade chronic inflammation damages the beta cells of the pancreas and leads to insufficient insulin secretion, resulting in high blood glucose. This review elaborates on the mechanism of inflammation in type 2 diabetes mellitus and the impact of LAIR-1 on its development.

Key words:

Type 2 diabetes mellitus, Leukocyte-associated immunoglobulin-like receptor-1, Inflammation, Insulin resistance, Review

摘要：

白细胞相关免疫球蛋白样受体1（LAIR-1）是一种免疫抑制受体，介导了免疫抑制，可以通过调节炎症反应来影响多种代谢性及免疫性疾病的发生发展。糖尿病是导致胰岛素产生缺陷的最常见的疾病形式。现在公认的是炎症反应是对高血糖水平免疫反应的结果，这种低度的慢性炎症损害了胰腺的β细胞，并导致胰岛素分泌不足，从而导致高血糖。在这篇综述中，我们重点讲述了糖尿病发生机制、炎症引起胰岛素抵抗导致糖尿病以及LAIR-1免疫激活后开启下游抑制信号通路调节炎症反应。

关键词:

2型糖尿病, 白细胞相关免疫球蛋白样受体1, 炎症, 胰岛素抵抗, 综述

Yang Lingyu, Jin Yongjun.

Leukocyte-associated immunoglobulin-like receptor 1 in diabetes [J]. International Medicine and Health Guidance News, 2023, 29(24): 3542-3545.

杨玲瑜金勇君.

白细胞相关免疫球蛋白样受体1在糖尿病中的研究现状 [J]. 国际医药卫生导报, 2023, 29(24): 3542-3545.

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