Roles of epigenetics and miRNA in depression

doi:10.3760/cma.j.issn.1007-1245.2023.13.002

Abstract

Abstract:

Depression, one of the most important types of modern mental illness, is a common emotional disorder with continuous and long-term depression as its main clinical feature. Recent studies have shown that dysexpression of miRNA is associated with a variety of human diseases, including cancer and psychology-related diseases, and miRNA plays an important role in the pathogenesis of depression and antidepressant treatment. Epigenetics refers to the biological phenomenon of long-term heritable gene function changes without changes in DNA sequence, including histone modification, DNA methylation, and miRNA regulation. Many studies have shown that dysregulation of epigenetic modification is the key to elucidating the pathogenesis of depression. This paper reviews the recent progress in epigenetic pathogenesis of depression and the role of miRNA in depression, in order to provide reference for the pathogenesis study and treatment of depression.

Key words:

Depression, Epigenetics, miRNA, DNA methylation, Histone modification, Review

摘要：

抑郁症是一种常见的情感障碍性精神疾病，以连续且长期的心情低落为主要临床特征，是现代人心理疾病最重要的类型之一。微RNA（miRNA）的表达失调与包括癌症和精神相关疾病在内的多种人类疾病有关，并且miRNA在抑郁症发病与抗抑郁治疗中起重要作用。表观遗传学是DNA序列不发生改变而产生长时程可遗传基因功能变化的生物学现象，其主要内容包括DNA甲基化、组蛋白修饰和miRNA调控等。很多研究表明，表观遗传学修饰失调是阐明抑郁症发病机制的关键。本文对近几年抑郁症表观遗传学发病机制以及miRNA在抑郁症中作用的研究进展进行综述，以期为抑郁症的发病机制的研究和治疗提供参考。

关键词:

抑郁症, 表观遗传, miRNA, DNA甲基化, 组蛋白修饰, 综述

Chen Guanhong, Yu Mingzi, Fang Yuhan, Cheng Xuefeng, Li Qi, Li Chen.

Roles of epigenetics and miRNA in depression [J]. International Medicine and Health Guidance News, 2023, 29(13): 1782-1786.

陈冠宏于茗子方雨涵程雪峰李奇李晨.

表观遗传与miRNA在抑郁症中的作用 [J]. 国际医药卫生导报, 2023, 29(13): 1782-1786.

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