Regulation of integron-cassette system expression in bacteria

doi:10.3760/cma.j.issn.1007-1245.2023.12.002

Abstract

Abstract:

The problem of bacterial drug resistance has become a global problem. Acquisition of exogenous antimicrobial resistant genes through horizontal gene transfer is the main reason for the emergence and dissemination of antimicrobial resistant bacteria. Integrons are mobile gene element that can capture and express drug resistance genes through site-specific recombination which were first proposed in 1989 and play an important role in bacterial drug resistance. Integrons allow bacteria to quickly respond to changes in selective pressure by recombining resistance gene cassettes of varying sizes. In order to increase the selective advantage of bacteria, the expression of integrons and gene cassettes are strictly regulated to reduce the adaptive cost to host bacteria. This paper reviews the concept, structure, and function of integrons and the mechanism of the expression regulation of integron-cassette system.

Key words:

Drug resistance, Integrons, Gene cassette, Expression regulation, Progress

摘要：

细菌耐药问题已成为全球性难题，细菌通过基因水平转移，获得外源性耐药基因是临床耐药菌株产生与播散的重要原因。整合子作为一种移动性基因元件于1989年首次被提出，其可以通过位点特异性重组的方式捕获和表达耐药基因，在细菌耐药方面有着重要作用。基因盒由大小不等的耐药基因组成，整合子通过对基因盒重组使细菌能够快速应对选择压力的改变。为了增加细菌的选择优势，整合子和基因盒的表达受到严格调控，以减少对宿主细菌造成适应性代价。本文主要就整合子的概念、结构、功能及整合子-基因盒系统表达调控的机制进行综述。

关键词:

耐药性, 整合子, 基因盒, 表达调控, 进展

Wang Xiaotong, Dai Wanqin.

Regulation of integron-cassette system expression in bacteria [J]. International Medicine and Health Guidance News, 2023, 29(12): 1636-1639.

汪小桐戴碗琴.

细菌整合子-基因盒系统表达调控的研究进展 [J]. 国际医药卫生导报, 2023, 29(12): 1636-1639.

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