Abstract:

Stem cells are involved in tissue development, growth, repair, and regenerative therapy, and are the cornerstone of tissue and organ regeneration in the human body, with self-renewal and multidirectional differentiation potential. Mesenchymal stem cells (MSCs), a type of stem cells, are widely found in human umbilical cords, and are also one of the most commonly used stem cells in clinical practice. Neurodegenerative diseases are a class of chronic and progressive neuronal death and loss of function that occur with age, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, age-related hearing loss, etc., which seriously affect the quality of life of the elderly. With the increasing trend of global aging, the incidence rate of neurodegenerative diseases is increasing year by year, and has become a major challenge for global public health. In this paper, we searched the literatures through PubMed, OVID, China Knowledge Network, Wanfang Data, and other databases and summarized the relevant studies of MSCs in neurodegenerative diseases.

Key words:

Mesenchymal stem cells,  , Neurodegenerative diseases,  , Stem cells,  , Organoids,  , Regeneration,  , Progress

摘要：

干细胞参与组织发育、生长、修复及再生治疗，是人体中组织器官再生的基石，具有自我更新和多向分化潜能。间充质干细胞是干细胞的一种，广泛存在于人体脐带中，也是临床中最常用到干细胞之一。神经退行性疾病是一类随着年龄增长而发生慢性、进行性的神经元死亡和功能丧失疾病，包括阿尔茨海默病、帕金森病、肌萎缩侧索硬化症、年龄相关性听力损失等，严重影响老年人的生活质量。随着全球老龄化趋势的加剧，神经退行性疾病发病率逐年上升，成为全球公共卫生领域面临的重大挑战。本文通过PubMed、OVID、中国知网、万方等数据库进行文献检索，总结归纳间充质干细胞在神经退行性疾病中的相关研究。

关键词:

间充质干细胞, 神经退行性疾病, 干细胞, 类器官, 再生, 进展