Abstract:

Objective　To study the effect of Modified Buzhong Yiqi Decoction and acupoint application in the treatment of patients with overactive bladders. Methods　Ninety-one female patients with overactive bladders treated at Department of Urology, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2024 were selected for the randomized controlled trial, and were divided into an experimental group (30 case), a control group 1 (30 cases), and a control group 2 (31 cases) by the random number table method. The experimental group were (46.72±10.13) years old, with a disease course of (3.09±2.49) years. The control group 1 were (46.98±11.29) years old, with a disease course of (3.18±2.63) years. The control group 2 were (47.48±10.11) years old, with a disease course of (3.08±2.44) years. The experimental group were treated by modified Buzhong Yiqi Decoction and acupoint application, the control group 1 with solifenacin succinate, and the control group 2 with modified Buzhong Yiqi Decoction, for 12 weeks. The urination diary (urination times during day time and night, urgency to urinate, and urge incontinence), scores of life quality, and overactive bladder syndrome scores (OABSS) before the treatment and after 12 weeks' treatment, clinical efficacies, and incidence rates of adverse reactions were compared between the 3 groups. t and χ² tests were used for the statistical analysis. Results　The urination times during day time and night and times of urgency to urinate and urge incontinence in 24 h, OABSS, and scores of life quality before the treatment and after 12 weeks' treatment in the experimental group were (14.4±1.57) times, (3.5±0.71) times, (3.5±0.53) times, (2.5±0.53) times, 9.7±1.16, 3.9±0.88, (10.1±1.10) times, (2.1±0.57) times, (1.9±0.57) times, (1.2±0.42) times, 4.4±1.26, and 1.7±0.68; those in the control group 1 were (14.3±2.00) times, (3.5±0.53) times, (3.5±0.85) times, (2.4±0.52) times, 9.9±0.99, 3.9±0.74, (10.3±2.05) times, (2.3±0.48) times, (2.1±0.88) times, (1.2±0.42) times, 4.9±1.29, and 2.1±0.57; those in the control group 2 were (14.1±2.02) times, (3.5±0.97) times, (3.5±1.08) times, (2.6±0.52) times, 10.0±1.76, 3.6±0.84, (11.6±1.83) times, (2.6±0.70) times, (2.3±0.95) times, (1.7±0.48) times, 5.9±1.19, and 2.6±0.84; there were statistical differences in the above indicators between before and after the treatment in the 3 groups (t=20.146, 8.573, 9.798, 8.510, 17.667, 7.571, 26.833, 9.192, 8.571, 9.833, 16.842, 10.554, 11.180, 5.014, 4.649, 7.090, 9.462, and 4.610; all P0.05). The total effective rates of the experimental group, the control group 1, and the control group 2 were 83.3% (25/30), 76.7% (23/30), and 51.6% (16/31), with a statistical difference between the 3 groups (χ²=8.213; P=0.016). No serious adverse reactions occurred in the three groups, with good tolerance. Conclusion　Modified Buzhong Yiqi Decoction combined with acupoint application for patients with overactive bladders is effective and safe and can improve their treatment compliance.

Key words:

Overactive bladder, Modified Buzhong Yiqi Decoction, Acupoint application

摘要：

目的　探讨补中益气汤加减联合穴位敷贴治疗膀胱过度活动症（OAB）的效果。方法　回顾性分析，选取2022年1月至2024年3月在广东省中西医结合医院泌尿外科治疗的女性OAB患者91例作为研究对象，通过随机数字表法分为试验组（30例）、对照组1（30例）、对照组2（31例）。试验组年龄（46.72±10.13）岁，病程（3.09±2.49）年，口服补中益气汤加减联合穴位敷贴治疗；对照组1年龄（46.98±11.29）岁，病程（3.18±2.63）年，口服琥珀酸索利那新片治疗；对照组2年龄（47.48±10.11）岁，病程（3.08±2.44）年，口服补中益气汤加减治疗。均连续用药12周。对比3组患者治疗前、治疗12周后的排尿日记情况（白天排尿次数、夜尿次数、24 h尿急、24 h急迫性尿失禁）、生活质量评分、膀胱过度活动症状评分（OABSS）、临床疗效与不良反应情况。统计学方法采用t检验、χ²检验。结果　治疗前及治疗12周后，试验组患者白天排尿次数、夜尿次数、24 h尿急、24 h急迫性尿失禁、OABSS及生活质量评分分别为（14.4±1.57）次、（3.5±0.71）次、（3.5±0.53）次、（2.5±0.53）次、（9.7±1.16）分、（3.9±0.88）分，（10.1±1.10）次、（2.1±0.57）次、（1.9±0.57）次、（1.2±0.42）次、（4.4±1.26）分、（1.7±0.68）分；对照组1患者上述指标分别为（14.3±2.00）次、（3.5±0.53）次、（3.5±0.85）次、（2.4±0.52）次、（9.9±0.99）分、（3.9±0.74）分，（10.3±2.05）次、（2.3±0.48）次、（2.1±0.88）次、（1.2±0.42）次、（4.9±1.29）分、（2.1±0.57）分；对照组2患者上述指标分别为（14.1±2.02）次、（3.5±0.97）次、（3.5±1.08）次、（2.6±0.52）次、（10.0±1.76）分、（3.6±0.84）分，（11.6±1.83）次、（2.6±0.70）次、（2.3±0.95）次、（1.7±0.48）次、（5.9±1.19）分、（2.6±0.84）分；3组患者治疗前后上述指标比较，差异均有统计学意义（t=20.146、8.573、9.798、8.510、17.667、7.571、26.833、9.192、8.571、9.833、16.842、10.554、11.180、5.014、4.649、7.090、9.462、4.610，均P0.05）。试验组总有效率为83.3%（25/30），高于对照组1、对照组2的76.7%（23/30）、51.6%（16/31），3组患者总有效比较，差异有统计学意义（χ²=8.213，P=0.016）。3组患者治疗期间总体耐受性良好，均未出现严重不良反应。结论　补中益气汤加减联合穴位敷贴治疗OAB的疗效显著，安全性好，可提高患者治疗依从性。

关键词:

膀胱过度活动症, 补中益气汤加减, 穴位敷贴