Abstract:

Objective　To explore the effect of Chinese medicine Cangyi Yin in the treatment of hypertensive patients with phlegm-dampness constitution type. Methods　A total of 96 hypertensive patients with phlegm-dampness constitution type treated in Guangzhou Yuexiu District Traditional Chinese Medicine Hospital from January to September 2023 were collected as the research objects, and were divided into two groups by the random number table method, with 48 patients in each group. There were 25 males and 23 females in the control group, aged (57.91±10.78) years, and the course of disease was (5.62±1.25) years. There were 28 males and 20 females in the TCM group, aged (58.37±11.09) years, and the course of disease was (5.59±1.21) years. The control group was given routine clinical treatment, and the TCM group was given Chinese medicine Cangyi Yin on the basis of routine treatment for 12 weeks. The symptoms of phlegm-dampness constitution, levels of blood pressure, blood lipids, and inflammatory factors, and qualities of life of the two groups were compared and analyzed. Independent sample t test was used for inter-group comparison of the measurement data, paired t test was used for intra-group comparison of the measurement data, and χ² test was used for the count data. Results　After treatment, the total effective rate of the TCM group [89.58% (43/48)] was higher than that of the control group [72.92% (35/48)], with a statistically significant difference (χ²=4.376, P=0.036). After treatment, the symptom scores of chest tightness and abdominal distension, heavy body, mucus and phlegm at the mouth, and thick and greasy tongue coating in the TCM group were lower than those in the control group [(0.64±0.17) points vs. (2.37±0.41) points, (0.51±0.12) points vs. (2.29±0.15) points, (0.66±0.15) points vs. (2.18±0.49) points, (0.67±0.25) points vs. (2.33±0.47) points] (all P<0.05). After treatment, the levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in the TCM group were lower than those in the control group [(114.65±13.49) mmHg vs. (123.58±14.25) mmHg (1 mmHg = 0.133 kPa), (79.54±9.21) mmHg vs. (85.09±10.38) mmHg, (37.19±4.87) ng/L vs. (45.18±5.33) ng/L, (21.95±3.28) ng/L vs. (27.38±3.70) ng/L] (all P<0.05). After treatment, the levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in the TCM group were lower than those in the control group [(4.27±1.08) mmol/L vs. (6.18±1.15) mmol/L, (1.28±0.29) mmol/L vs. (2.05±0.34) mmol/L, (2.51±0.59) mmol/L vs. (3.71±0.73) mmol/L], while the level of high-density lipoprotein cholesterol (HDL-C) was higher than that in the control group [(1.97±0.35) mmol/L vs. (1.61±0.38) mmol/L] (all P<0.05). After treatment, the scores of physiological, psychological, environmental, and social dimensions of the WHOQOL-BREF in the TCM group were higher than those in the control group [(86.93±8.17) points vs. (58.34±8.32) points, (83.27±5.19) points vs. (59.52±5.34) points, (79.84±5.47) points vs. (55.87±5.29) points, (78.65±5.41) points vs. (60.41±5.82) points] (all P<0.05). Conclusion　The traditional Chinese medicine Cangyi Yin can improve the physical symptoms of hypertensive patients with phlegm-dampness constitution type, regulate the levels of blood pressure, blood lipids, and inflammatory factors, and improve their quality of life, which is worth promoting and applying.

Key words:

Hypertension, Phlegm-dampness constitution, Chinese medicine Cangyi Yin, Quality of life

摘要：

目的　观察中药苍薏饮在改善及治疗痰湿型高血压患者中的应用效果。方法　选择2023年1月至9月广州市越秀区中医医院收治的96例高血压患者，体质辨识均为痰湿体质。采用随机数字表法随机分成两组，每组48例。对照组男25例，女23例；年龄（57.91±10.78）岁；病程（5.62±1.25）年；给予常规临床治疗。中药组男28例，女20例；年龄（58.37±11.09）岁；病程（5.59±1.21）年；在常规治疗基础上增加中药苍薏饮治疗。两组均连续治疗12周。比较两组患者痰湿体质症状、血压、血脂、炎症因子水平及生活质量情况。采用独立样本t检验、配对t检验和χ²检验。结果　治疗后，中药组总有效率［89.58%（43/48）］高于对照组［72.92%（35/48）］，差异有统计学意义（χ²=4.376，P=0.036）；治疗后，中药组胸闷腹胀、身体沉重、口黏痰多、舌苔厚腻症状评分均低于对照组［（0.64±0.17）分比（2.37±0.41）分，（0.51±0.12）分比（2.29±0.15）分，（0.66±0.15）分比（2.18±0.49）分，（0.67±0.25）分比（2.33±0.47）分］（均P<0.05）；治疗后，中药组收缩压（SBP）、舒张压（DBP）、肿瘤坏死因子-α（TNF-α）、白细胞介素6（IL-6）水平均低于对照组［（114.65±13.49）mmHg比（123.58±14.25）mmHg（1 mmHg=0.133 kPa），（79.54±9.21）mmHg比（85.09±10.38）mmHg，（37.19±4.87）ng/L比（45.18±5.33）ng/L，（21.95±3.28）ng/L比（27.38±3.70）ng/L］（均P<0.05）；治疗后，中药组总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）水平均低于对照组［（4.27±1.08）mmol/L比（6.18±1.15）mmol/L，（1.28±0.29）mmol/L比（2.05±0.34）mmol/L，（2.51±0.59）mmol/L比（3.71±0.73）mmol/L］，高密度脂蛋白胆固醇（HDL-C）水平高于对照组［（1.97±0.35）mmol/L比（1.61±0.38）mmol/L］（均P<0.05）；治疗后，中药组世界卫生组织生活质量简表（WHOQOL-BREF）中生理、心理、环境及社会维度评分均高于对照组［（86.93±8.17）分比（58.34±8.32）分，（83.27±5.19）分比（59.52±5.34）分，（79.84±5.47）分比（55.87±5.29）分，（78.65±5.41）分比（60.41±5.82）分］（均P<0.05）。结论　中药苍薏饮可改善痰湿体质高血压患者的体质症状，调节患者血压、血脂、炎症因子水平，提高患者生活质量，值得推广和应用。

关键词:

高血压, 痰湿体质, 中药苍薏饮, 生活质量