Research progress on mechanism of ferroptosis in Alzheimer's disease

doi:10.3760/cma.j.issn.1007-1245.2024.05.001

Abstract

Abstract:

Alzheimer's disease is a neurodegenerative disease characterized by chronic neuroinflammation, and poses a serious medical challenge and burden worldwide. As an iron-dependent form of cell death characterized by iron accumulation, lipid peroxidation, disturbance of amino acid metabolism, and irreversible disruption of the plasma membrane. Ferroptosis may be associated with neurological dysfunction in Alzheimer's disease. This article reviews the role of ferroptosis in the pathologic progression of Alzheimer's disease through iron, lipid, and amino acid metabolisms, and the potential therapeutic measures for inhibiting ferroptosis in Alzheimer's disease. It is expected that ferroptosis will provide new insights into the pathogenesis and preventive treatment of Alzheimer's disease.

Key words:

Alzheimer's disease, Ferroptosis, Iron metabolism, Lipid peroxidation, Progress

摘要：

阿尔茨海默病（AD）是以慢性神经炎症为特征的神经退行性疾病，在世界范围内构成了严重的医疗挑战和医疗负担。铁死亡作为一种依赖铁的细胞死亡形式，以铁积累、脂质过氧化、氨基酸代谢紊乱和不可逆的质膜破坏为特征，可能与AD的神经功能障碍有关。本文综述铁死亡通过铁代谢、脂质代谢和氨基酸代谢机制参与AD的病理进展，以及抑制铁死亡在AD中的潜在治疗措施。期望以铁死亡为切入点，为AD的发生机制和预防治疗提供新见解。

关键词:

阿尔茨海默病, 铁死亡, 铁代谢, 脂质过氧化, 进展

Zheng Mei, Lu Ying, Mu Dawei.

Research progress on mechanism of ferroptosis in Alzheimer's disease [J]. International Medicine and Health Guidance News, 2024, 30(5): 705-709.

郑梅陆颖木大为.

铁死亡在阿尔茨海默病中的作用机制及研究进展 [J]. 国际医药卫生导报, 2024, 30(5): 705-709.

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