Abstract:

As a common malignant tumor in women, breast cancer has risen to the top of female malignant tumors, and has serious impact on women's health. At present, although there are various treatment methods for breast cancer, due to the high degree of malignancy and chemotherapy resistance of patients, the clinical treatment effect is not good, which seriously affects the patients' prognosis and survival. Iron death is a novel form of cell death characterized by intracellular iron overexpression and lipid reactive oxygen species accumulation. Studies have found that iron death is related to the occurrence, development, and evolution of breast cancer, so inducing iron death can inhibit the proliferation and distant metastasis of breast cancer cells, enhance the efficacy of chemotherapy drugs, and reverse the chemotherapy resistance of breast cancer. Therefore, inducing iron death may become a new strategy for clinical treatment of patients with breast cancer. In this paper, the mechanism of chemotherapy resistance and iron death in breast cancer and the research progress in the treatment of patients with breast cancer are reviewed.

Key words:

Iron death, Breast cancer, Chemotherapy, Chemotherapy resistance, Progress

摘要：

乳腺癌作为女性常见的恶性肿瘤，已跃居女性恶性肿瘤之首，对女性健康产生严重影响。目前，虽然乳腺癌的治疗方法多种多样，但是由于患者存在恶性程度高、化疗耐药等问题，使得其临床治疗效果不佳，严重影响患者预后和生存。铁死亡作为一种新型的细胞死亡形式，以细胞内铁过表达和脂质活性氧累积为特征。研究发现，铁死亡与乳腺癌的发生发展及演进有关，并且诱导铁死亡可以抑制乳腺癌细胞的增殖及远处转移，增强其化疗药物的疗效，进而逆转乳腺癌化疗耐药。因此，诱导铁死亡可成为乳腺癌患者临床治疗的新策略。本文对乳腺癌化疗耐药、铁死亡作用机制及其在乳腺癌患者治疗中的研究进展进行综述。

关键词:

铁死亡, 乳腺癌, 化疗, 化疗耐药, 进展