Overviews of the effect of exercise on chemotherapy-induced peripheral neuropathy

doi:10.3760/cma.j.issn.1007-1245.2024.16.020

Abstract

Abstract:

Objective　To evaluate the systematic reviews of the effect of exercise on chemotherapy-induced peripheral neuropathy, with a view to provide a basis for the development of exercise intervention programs for patients with peripheral neuropathy due to cancer chemotherapy. Methods　Systematic reviews/meta-analysis of the effect of exercise on chemotherapy-induced peripheral neuropathy were searched in nine databases by combining subject terms with free words: CNKI, Wangfang, VIP, CBM, PubMed, Web of Science, EMBASE, The Cochrane Library, and CINAHL. The search time limit was from the inception of the database until August 20, 2023, and the literatures obtained were independently screened and extracted by two researchers. Results　A total of 9 systematic reviews/meta-analyses were included, and the methodological quality assessment of the systematic reviews showed that 3 were of low quality and 6 were of very low quality. The grades of recommendations assessment, development and evaluation (GRADE) grading of the 23 pieces of evidence showed 1 piece of high-level evidence, 5 pieces of intermediate evidence, 9 pieces of low-level evidence, and 8 pieces of extremely-low-level evidence. Conclusion　The systematic reviews/meta-analysis of the literatures on the effect of exercise on chemotherapy-induced peripheral neuropathy are of generally low quality, with low volume and overall strength of evidences, and multicenter, large-sample, high-quality studies are still needed to further assess its effect in the future.

Key words:

Cancer, Chemotherapy, Peripheral neuropathy, Exercise, Evidence-based nursing, Overview of systematic review

摘要：

目的　就运动对化疗致周围神经病变干预效果的系统评价进行再评价，以期为癌症化疗致周围神经病变患者制定运动干预方案提供依据。方法　通过主题词结合自由词的方式，用计算机系统检索9个数据库：PubMed、Web of Science、EMBASE、The Cochrane Library、CINAHL、中国知网（CNKI）、万方数据库（Wangfang）、维普数据库（VIP）以及中国生物医学文献数据库（CBM），检索运动对化疗致周围神经病变影响的系统评价/meta分析，检索时限为建库至2023年8月20日，由两名研究者独立对检索获得的文献进行筛选和数据提取。结果　经过筛选后共纳入9篇系统评价/meta分析，系统评价方法学质量评价结果为3篇文献低质量、6篇文献极低质量。对23条证据进行推荐分级的评估、制定与评价（GRADE）分级，得到高级证据1条、中级证据5条、低级证据9条、极低级证据8条。结论　运动对化疗致周围神经病变效果的系统评价/meta分析文献质量总体不高，证据数量较少且总体证据强度较低，未来仍需严谨规范地开展多中心、大样本研究，以提供更高质量的证据。

关键词:

癌症, 化疗, 周围神经病变, 运动, 循证护理, 系统评价再评价

Zhang Xinyue, Liu Jingyuan, Zhang Fan, Zhou Wenqin.

Overviews of the effect of exercise on chemotherapy-induced peripheral neuropathy [J]. International Medicine and Health Guidance News, 2024, 30(16): 2732-2737.

张馨悦刘静媛张帆周文琴.

运动对化疗致周围神经病变效果的系统评价再评价 [J]. 国际医药卫生导报, 2024, 30(16): 2732-2737.

References

[1] Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3):209-249. DOI: 10.3322/caac.21660.
[2] Staff NP, Grisold A, Grisold W, et al. Chemotherapy-induced peripheral neuropathy: a current review[J]. Ann Neurol, 2017, 81(6):772-781. DOI: 10.1002/ana.24951.
[3] Miller KD, Nogueira L, Devasia T, et al. Cancer treatment and survivorship statistics, 2022[J]. CA Cancer J Clin, 2022, 72(5):409-436. DOI: 10.3322/caac.21731.
[4] Seretny M, Currie GL, Sena ES, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis[J]. Pain, 2014, 155(12):2461-2470. DOI: 10.1016/j.pain.2014.09.020.
[5] Desforges AD, Hebert CM, Spence AL, et al. Treatment and diagnosis of chemotherapy-induced peripheral neuropathy: an update[J]. Biomed Pharmacother, 2022, 147:112671. DOI: 10.1016/j.biopha.2022.112671.
[6] 赵顺莹,徐哲,刘婷,等.癌症患者对化疗致周围神经病变体验质性研究的系统评价[J].护理管理杂志,2020,20(5):339-344. DOI:10.3969/j.issn.1671-315x.2020.05.008.
[7] Burgess J, Ferdousi M, Gosal D, et al. Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment[J]. Oncol Ther, 2021, 9(2):385-450. DOI: 10.1007/s40487-021- 00168-y.
[8] Nicolini C, Fahnestock M, Gibala MJ, et al. Understanding the neurophysiological and molecular mechanisms of exercise-induced neuroplasticity in cortical and descending motor pathways: where do we stand?[J]. Neuroscience, 2021, 457:259-282. DOI: 10.1016/j.neuroscience.2020.12.013.
[9] Nuñez de Arenas-Arroyo S, Cavero-Redondo I, Torres-Costoso A, et al. Effects of exercise interventions to reduce chemotherapy-induced peripheral neuropathy severity: a meta-analysis[J]. Scand J Med Sci Sports, 2023, 33(7):1040-1053. DOI: 10.1111/sms.14360.
[10] 张莹,李之华,刘子晗.运动疗法防治肿瘤患者化疗所致周围神经病变效果的Meta分析[J].现代临床护理,2023,22(5):72-79. DOI:10.3969/j.issn.1671-8283.2023.05.011.
[11] 张方圆,沈傲梅,曾宪涛,等.系统评价方法学质量评价工具AMSTAR 2解读[J].中国循证心血管医学杂志,2018,10(1):14-18. DOI:10.3969/j.issn.1674-4055.2018.01.03.
[12] 陶欢,杨乐天,平安,等.随机或非随机防治性研究系统评价的质量评价工具AMSTAR2解读[J].中国循证医学杂志,2018,18(1):101-108. DOI:10.7507/1672-2531. 201711005.
[13] 陈耀龙,姚亮,Susan Norris,等.GRADE在系统评价中应用的必要性及注意事项[J].中国循证医学杂志,2013,13(12):1401-1404. DOI:10.7507/1672-2531.20130240.
[14] Howard Balshem, Mark Helfanda, Holger J. Schunemann, 等.GRADE指南:Ⅲ.证据质量分级[J].中国循证医学杂志,2011,11(4):451-455. DOI:10.3969/j.issn.1672-2531. 2011.04.017.
[15] Gordon H. Guyatt, Andrew D. Oxman, Gunn Vist, 等.GRADE指南:Ⅳ.证据质量分级——研究的局限性(偏倚风险)[J].中国循证医学杂志,2011,11(4):456-463. DOI:10.3969/j.issn.1672-2531.2011.04.018.
[16] Gordon H.Guyatt, Andrew D.Oxman, Victor Montori, 等.GRADE指南:Ⅴ.证据质量评价——发表偏倚[J].中国循证医学杂志,2011,11(12):1430-1434. DOI:10.3969/j.issn.1672-2531.2011.12.015.
[17] Gordon Guyatt, Andrew D.Oxman, Regina Kunz, 等.GRADE指南:Ⅵ.证据质量评价——不精确性(随机误差)[J].中国循证医学杂志,2011,11(12):1435-1443. DOI:10.3969/j.issn.1672-2531.2011.12.016.
[18] Gordon H.Guyatt, Andrew D.Oxman, Regina Kunz, 等.GRADE指南:Ⅶ.证据质量评价——不一致性[J].中国循证医学杂志,2011,11(12):1444-1451. DOI:10.3969/j.issn.1672-2531.2011.12.017.
[19] Gordon Guyatt, Andrew D.Oxman, Regina Kunz, 等.GRADE指南:Ⅷ.证据质量评价——间接性[J].中国循证医学杂志,2011,11(12):1452-1458. DOI:10.3969/j.issn.1672-2531. 2011.12.018.
[20] Guo S, Han W, Wang P, et al. Effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis[J]. J Cancer Surviv, 2023, 17(2):318-331. DOI: 10.1007/s11764-022-01182-3.
[21] Dixit S, Tapia V, Sepúlveda C, et al. Effectiveness of a therapeutic exercise program to improve the symptoms of peripheral neuropathy during chemotherapy: systematic review of randomized clinical trials[J]. Life (Basel), 2023, 13(2):262. DOI: 10.3390/life13020262.
[22] Brownson-Smith R, Orange ST, Cresti N, et al. Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis[J]. J Cancer Surviv, 2023. DOI: 10.1007/s11764-023-01450-w.
[23] Lopez-Garzon M, Cantarero-Villanueva I, Postigo-Martin P, et al. Can physical exercise prevent chemotherapy-induced peripheral neuropathy in patients with cancer? A systematic review and meta-analysis[J]. Arch Phys Med Rehabil, 2022, 103(11):2197-2208. DOI: 10.1016/j.apmr.2022.02.008.
[24] Lin WL, Wang RH, Chou FH, et al. The effects of exercise on chemotherapy-induced peripheral neuropathy symptoms in cancer patients: a systematic review and meta-analysis[J]. Support Care Cancer, 2021, 29(9):5303-5311. DOI: 10.1007/s00520-021-06082-3.
[25] Tanay MAL, Armes J, Moss-Morris R, et al. A systematic review of behavioural and exercise interventions for the prevention and management of chemotherapy-induced peripheral neuropathy symptoms[J]. J Cancer Surviv, 2023, 17(1):254-277. DOI: 10.1007/s11764-021- 00997-w.
[26] Duregon F, Vendramin B, Bullo V, et al. Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: a systematic review[J]. Crit Rev Oncol Hematol, 2018, 121:90-100. DOI: 10.1016/j.critrevonc.2017.11.002.
[27] Park SB, Goldstein D, Krishnan AV, et al. Chemotherapy-induced peripheral neurotoxicity: a critical analysis[J]. CA Cancer J Clin, 2013, 63(6):419-437. DOI: 10.3322/caac.21204.
[28] 陈思诺,李珍,陈露娜,等.化疗致周围神经病变病人报告结局评估工具研究进展[J].全科护理,2023,21(24):3350-3354. DOI:10.12104/j.issn.1674-4748.2023.24.009.
[29] Loprinzi CL, Lacchetti C, Bleeker J, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update[J]. J Clin Oncol, 2020, 38(28):3325-3348. DOI: 10.1200/JCO.20.01399.
[30] 中国中西医结合疼痛学会,中国抗癌协会中西医整合专业委员会,中国中医药研究促进会.化疗所致周围神经病理性疼痛中西医诊治专家共识[J].中华肿瘤防治杂志,2021,28(23):1761-1767,1779. DOI:10.16073/j.cnki.cjcpt.2021. 23.01.