Abstract:

Objective　To investigate the correlations between hemorheology and blood lipids in elderly patients with sudden deafness (SD). Methods　A total of 82 elderly SD patients admitted to Changsha Central Hospital from August 2020 to August 2022 were selected, including 50 males and 32 females, aged (68.73±5.17) years. Another 60 healthy individuals who came to our hospital for physical examination during the same period were selected as a control group, including 34 males and 26 females, aged (69.01±5.33) years. The hemorheology indexes and blood lipid indexes of the two groups of subjects were detected, and according to the type of hearing loss, the elderly SD patients were divided into a low-frequency decline type (18 cases), a high-frequency decline type (22 cases), a flat decline type (33 cases), and a total deafness type (9 cases). The differences of hemorheology and blood lipid levels among all groups were compared, and the correlations between impaired frequency hearing threshold and hemorheology and blood lipid levels were analyzed. χ² test, t/F test, and Spearman correlation analysis were used for statistical analysis. Results　The levels of whole blood viscosity (WBV) [(5.75±1.24) mPa·s vs. (3.50±0.87) mPa·s], red cell assembling index (RCAI) [(4.69±1.01) vs. (2.83±0.58)], fibrinogen (Fib) [(4.25±0.94) g/L vs. (2.30±0.55) g/L], total cholesterol (TC) [(5.36±1.12) mmol/L vs. (3.12±0.88) mmol/L], triglyceride (TG) [(4.25±1.08) mmol/L vs. (2.40±0.75) mmol/L], and low density lipoprotein cholesterol (LDL-C) [(3.22±1.06) mmol/L vs. (1.90±0.74) mmol/L] in the SD group were higher than those in the control group, and the level of high density lipoprotein cholesterol (HDL-C) [(0.94±0.33) mmol/L vs. (1.15±0.40) mmol/L] was lower than that in the control group (all P<0.05). The levels of WBV, RCAI, Fib, TC, TG, and LDL-C in the total deafness type group were (6.92±1.39) mPa·s, (5.45±1.26), (5.09±1.15) g/L, (7.06±1.40) mmol/L, (5.48±1.30) mmol/L, and (4.45±1.29) mmol/L, those in the flat decline type group were (5.81±1.43) mPa·s, (4.85±1.08), (4.48±1.01) g/L, (5.89±1.16) mmol/L, (4.82±1.11) mmol/L, and (3.83±1.09) mmol/L, those in the high-frequency decline type group were (5.30±1.20) mPa·s, (4.46±0.92), (3.73±0.90) g/L, (5.07±1.07) mmol/L, (4.07±0.98) mmol/L, and (3.12±0.98) mmol/L, and those in the low-frequency decline type group were (4.05±0.99) mPa·s, (3.52±0.87), (2.89±0.75) g/L, (3.12±0.88) mmol/L, (3.45±0.90) mmol/L, and (2.86±0.87) mmol/L; the levels of WBV, RCAI, Fib, TC, TG, and LDL-C in the total deafness type group were higher than those in the other three groups (all P<0.05). The HDL-C level in the total deafness type group was lower than that in the flat decline type, high-frequency decline, and low-frequency decline type groups [(0.61±0.20) mmol/L vs. (0.78±0.29) mmol/L, (0.87±0.33) mmol/L, (1.02±0.38) mmol/L], with a statistically significant difference (P<0.05). Spearman correlation analysis showed that the impaired hearing thresholds of low-frequency decline and high-frequency decline types were positively correlated with WBV (r=0.510 and 0.562, both P<0.05); the impaired hearing thresholds of low-frequency decline, high-frequency decline, flat decline, and total deafness types were negatively correlated with HDL-C (r=-0.539, -0.443, -0.495, and -0.683; all P<0.05). Conclusions　Elderly SD patients have abnormal hemorheology and blood lipids. The impaired hearing threshold is positively correlated with WBV and negatively correlated with HDL-C. Monitoring the above indicators is beneficial to the diagnosis and treatment of elderly SD patients.

Key words:

Sudden deafness, Aged, Hemorheology, Blood lipids, Correlation

摘要：

目的　探讨老年突发性聋（SD）患者血流变学和血脂的相关性。方法　收集2020年8月至2022年8月长沙市中心医院收治的82例老年SD患者，其中男50例，女32例，年龄（68.73±5.17）岁；另选取同期来体检的健康者60例为对照组，其中男34例，女26例，年龄（69.01±5.33）岁。检测两组受试者血流变学指标和血脂指标，并根据听力损失类型将老年SD患者分为低频下降型（18例）、高频下降型（22例）、平坦下降型（33例）和全聋型（9例）。比较各组血流变学、血脂水平差异，并分析受损频率听阈与血流变学和血脂的关系，采用χ²检验、t/F检验和Spearman相关性分析进行统计学分析。结果　老年SD组全血黏度（WBV）［（5.75±1.24）mPa·s比（3.50±0.87）mPa·s］、红细胞聚集指数（RCAI）［（4.69±1.01）比（2.83±0.58）］、纤维蛋白原（Fib）［（4.25±0.94）g/L比（2.30±0.55）g/L］、总胆固醇（TC）［（5.36±1.12）mmol/L比（3.12±0.88）mmol/L］、三酰甘油（TG）［（4.25±1.08）mmol/L比（2.40±0.75）mmol/L］及低密度脂蛋白胆固醇（LDL-C）［（3.22±1.06）mmol/L比（1.90±0.74）mmol/L］水平均高于对照组，高密度脂蛋白胆固醇（HDL-C）［（0.94±0.33）mmol/L比（1.15±0.40）mmol/L］水平低于对照组（均P<0.05）。全聋型患者的WBV、RCAI、Fib、TC、TG及LDL-C水平分别为（6.92±1.39）mPa·s、（5.45±1.26）、（5.09±1.15）g/L、（7.06±1.40）mmol/L、（5.48±1.30）mmol/L、（4.45±1.29）mmol/L，平坦下降型分别为（5.81±1.43）mPa·s、（4.85±1.08）、（4.48±1.01）g/L、（5.89±1.16）mmol/L、（4.82±1.11）mmol/L、（3.83±1.09）mmol/L，高频下降型分别为（5.30±1.20）mPa·s、（4.46±0.92）、（3.73±0.90）g/L、（5.07±1.07）mmol/L、（4.07±0.98）mmol/L、（3.12±0.98）mmol/L，低频下降型分别为（4.05±0.99）mPa·s、（3.52±0.87）、（2.89±0.75）g/L、（3.12±0.88）mmol/L、（3.45±0.90）mmol/L、（2.86±0.87）mmol/L，全聋型患者的WBV、RCAI、Fib、TC、TG及LDL-C水平均高于平坦下降型、高频下降型及低频下降型患者（均P<0.05）；全聋型患者的HDL-C水平均低于平坦下降型、高频下降型及低频下降型患者［（0.61±0.20）mmol/L比（0.78±0.29）mmol/L、（0.87±0.33）mmol/L、（1.02±0.38）mmol/L］，差异有统计学意义（P<0.05）。Spearman相关性分析显示，低频下降型、高频下降型受损听阈均与WBV呈正相关（r=0.510、0.562，均P<0.05），低频下降型、高频下降型、平坦下降型及全聋型受损听阈均与HDL-C呈负相关（r=-0.539、-0.443、-0.495、-0.683，均P<0.05）。结论　老年SD患者存在血流变学和血脂异常，且受损听阈与WBV呈正相关，与HDL-C呈负相关，对上述指标进行监测有利于老年SD患者的临床诊断和治疗。

关键词:

突发性聋, 老年人, 血流变学, 血脂, 相关性