Relationships between serum chromogranin A, Apelin, and H-FABP and myocardial injury in
children with sepsis

doi:10.3760/cma.j.issn.1007-1245.2022.02.004

International Medicine and Health Guidance News ›› 2022, Vol. 28 ›› Issue (2): 163-166.DOI: 10.3760/cma.j.issn.1007-1245.2022.02.004

• Scientific Research • Previous Articles Next Articles

Relationships between serum chromogranin A, Apelin, and H-FABP and myocardial injury in children with sepsis

Xiao Haiping¹ , Cui Junhao²

¹Clinical Laboratory, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou Key Laboratory of Pediatric Infection and Immunization, Zhengzhou 450000, China; ²Emergency Department, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou Key Laboratory of Pediatric Infection and Immunization, Zhengzhou 450000, China

Received:2021-08-10 Online:2022-01-15 Published:2022-03-07
Contact: Cui Junhao, Email: cuijunhao414@163.com
Supported by:
Key Project of Medical Science and Technology in Henan Province (LHGJ20200619)

脓毒症患儿血清嗜铬粒蛋白A、Apelin、 H-FABP与心肌损伤的关系探讨

肖海平¹ 崔君浩²

¹ 郑州大学附属儿童医院河南省儿童医院郑州儿童医院郑州市儿童感染与免疫重点实验室检验科，郑州 450000；²郑州大学附属儿童医院河南省儿童医院郑州儿童医院郑州市儿童感染与免疫重点实验室急诊科，郑州 450000

通讯作者: 崔君浩，Email：cuijunhao414@163.com
基金资助:
河南省医学科技攻关重点项目（LHGJ20200619）

Abstract

Abstract: Objective To explore the relationships between serum chromogranin A (CHGA), plasma Apelin, and heart-type fatty acid binding protein (H-FABP) levels and myocardial injury in children with sepsis. Methods A total of 100 children with sepsis, 60 boys and 40 girls, aged 7-12 years, with a course of disease of 2-24 d, who were admitted to Children's Hospital Affiliated of Zhengzhou University between April 2018 and April 2021 were selected, and were divided into a myocardial injury group (53 cases) and a non-myocardial injury group (47 cases) according to the echocardiography results within 3 hours after admission. The levels of CHGA, Apelin, and H-FABP 3 and 6 hours after admission were compared between the two groups.Independent sample t test was used for measurement data, and χ2 test was used for count data. The relationships between CHGA, Apelin, and H-FABP levels and myocardial injury in children with sepsis were analyzed through multivariate logistic regression analysis. Results The myocardial injury group had higher CHGA levels, and lower Apelin and H-FABP levels than the non-myocardial injury group 3 and 6 hours after admission (all P<0.05). Multivariate logistic regression analysis showed that the levels of CHGA, Apelin, and H-FABP in children with sepsis were risk factors for myocardial injury (all OR>1, P<0.05). Conclusion Higher CHGA level and lower Apelin and H-FABP levels are related to myocardial injury in children with sepsis.

Key words: Sepsis, Serum chromogranin A, Plasma Apelin, Heart-type fatty acid binding protein, Myocardial injury, Correlation

摘要： 目的探究脓毒症患儿血清嗜铬粒蛋白 A（CHGA）、血浆爱帕琳肽（Apelin）、心型脂肪酸结合蛋白（H-FABP）水平与心肌损伤的关系。方法选取郑州大学附属儿童医院2018年4月至2021年4月收治的脓毒症患儿100例，男60例、女40例，年龄7～12岁，病程2～24 d。根据入院3h内的超声心动图结果，将患儿分为心肌损伤组53例和非心肌损伤组47例，分别检测并比较两组患儿入院3h、6h的CHGA、Apelin、H-FABP水平。计量资料采用独立样本t检验，计数资料采用χ2检验，用多因素logistic回归分析脓毒症患儿CHGA、Apelin、H-FABP水平与心肌损伤的关系。结果入院3h、6h 后，心肌损伤组的 CHGA 水平较非心肌损伤组高，Apelin、H-FABP 水平较非心肌损伤组低（均 P< 0.05）。多因素 logistic 回归分析显示，脓毒症患儿 CHGA、Apelin、H-FABP 水平为心肌损伤的危险因素（均OR>1，P<0.05）。结论较高CHGA水平以及较低Apelin和H-FABP水平与脓毒症患儿的心肌损伤有关。

关键词: 脓毒症, 血清嗜铬粒蛋白 A, 血浆爱帕琳肽, 心型脂肪酸结合蛋白, 心肌损伤, 相关性

Xiao Haiping , Cui Junhao. Relationships between serum chromogranin A, Apelin, and H-FABP and myocardial injury in children with sepsis[J]. International Medicine and Health Guidance News, 2022, 28(2): 163-166.

肖海平, 崔君浩. 脓毒症患儿血清嗜铬粒蛋白A、Apelin、 H-FABP与心肌损伤的关系探讨[J]. 国际医药卫生导报, 2022, 28(2): 163-166.

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Relationships between serum chromogranin A, Apelin, and H-FABP and myocardial injury in children with sepsis

脓毒症患儿血清嗜铬粒蛋白A、Apelin、 H-FABP与心肌损伤的关系探讨

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