Abstract:

Objective　To investigate the effect of Gushen Yutai ecological therapy combined with psychotherapy on the efficacy, pregnancy rate, constitution, anxiety state, and sex hormones [follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), and prolactin (PRL)] of infertile patients with qi-depression constitution polycystic ovarian syndrome (PCOS). Methods　From January 2021 to June 2022, 128 infertile patients with qi-depression constitution PCOS who were treated in Shantou Central Hospital and Department of Gynecology of Traditional Chinese Medicine (TCM), Rehabilitation Branch, Shantou Central Hospital and who met the inclusion criteria were selected. They were divided into group A who were 24-36 years old, group B who were 23-40 years old, group C who were 25-38 years old, and group D who were 25-42 years old according to the principle of randomized control, with 32 cases in each group. Group A took routine therapy. Group B took Gushen Yutai ecological therapy and routine therapy. Group C took Gushen Yutai ecological therapy, routine therapy, and mental therapy. Group D took Gushen Yutai ecological therapy, routine therapy, mental therapy, and four-season music assisted pregnancy therapy. One menstrual cycle was taken as a treatment course. After three treatment courses, the clinical pregnancy conditions, TCM constitution classifications, scores of determination self-test scale (CCMQ) qi-depression constitution and Self-Rating Anxiety Scale (SAS), and basic sex hormone levels before and after the treatment in the four groups were compared. χ² test and analysis of variance were applied. Results　The clinical pregnancy rates of group A, B, C, and D were 28.13% (9/32), 53.13% (17/32), 56.25% (18/32), and 58.38% (19/32), respectively, with statistical differences between group B, C, and D and group A (all P<0.05). The scores of CCMQ qi-depression constitution and SAS in group C and D were significantly better as compared with those before the treatment, with statistical differences (all P<0.05); the scores in group D were better than those in group A and B after the treatment, with statistical differences (all P<0.05). The total effective rates of group A, B, C, and D were 50.00% (16/32), 90.63% (29/32), 90.63% (29/32), and 93.75% (30/32), respectively, with statistical differences between group B, C, and D and group A (all P<0.05). After the treatment, the levels of LH and PRL in group D were much better than those in group A, with statistical differences (both P<0.05). Conclusion　Gushen Yutai ecological therapy combined with conventional therapy and psychotherapy can effectively improve the anxiety of infertile patients with qi-depression constitution PCOS and their physique, regulate the levels of sexual hormones, and increase the pregnancy rate.

Key words:

Gushen Yutai ecological therapy, Qi-depression constitution, PCOS, Infertility

摘要：

目的　探讨基于固肾育胎生态疗法的精神疗法对气郁质多囊卵巢综合征（PCOS）不孕患者的疗效、妊娠率、体质、焦虑状态、性激素水平［卵泡生成激素（FSH）、黄体生成激素（LH）、雌二醇（E2）、睾酮（T）、催乳激素（PRL）］的影响。方法　采用试验研究，选取2021年1月至2022年6月就诊于汕头市中心医院和汕头市中心医院康复分院中医妇科，符合纳入标准的128例气郁质PCOS不孕患者，按照随机对照分组原则平均分为A、B、C、D组。A组32例，年龄24～36岁，采用常规疗法；B组32例，年龄23～40岁，采用固肾育胎生态疗法+常规疗法；C组32例，年龄25～38岁，采用固肾育胎生态疗法+常规疗法+精神疏导疗法；D组32例，年龄25～42岁，采用固肾育胎生态疗法+常规疗法+精神疏导疗法+四季音乐助孕疗法。以1个月经周期为1个疗程，治疗3个疗程后，比较4组的临床妊娠情况和治疗前后中医体质分类与判定自测表（CCMQ）气郁质评分、焦虑自评量表（SAS）评分、基础性激素水平。采用χ²检验、方差分析进行统计分析。结果　A组临床妊娠率为28.13%（9/32），B组为53.13%（17/32），C组为56.25%（18/32），D组为58.38%（19/32），B、C、D组与A组比较，差异均有统计学意义（均P<0.05）。CCMQ气郁质评分和SAS评分结果：C组、D组与治疗前比较改善明显，差异均有统计学意义（均P<0.05）；D组治疗后与A、B组同期比较，差异均有统计学意义（均P<0.05）。A组总有效率为50.00%（16/32），B组为90.63%（29/32），C组为90.63%（29/32），D组为93.75%（30/32），B、C、D组与A组比较，差异均有统计学意义（均P<0.05）。治疗后，D组的LH和PRL水平较A组明显改善，差异均有统计学意义（均P<0.05）。结论　基于固肾育胎生态疗法的精神疗法联合常规疗法可有效改善气郁质PCOS不孕患者的焦虑情绪，改善体质，调节性激素水平，提高妊娠率。

关键词:

多囊卵巢综合征, 固肾育胎生态疗法, 精神疗法, 气郁质, 不孕